The obesity epidemic has forced us to evaluate the role of inflammation in the health
complications of obesity. This has led to a convergence of the fields of immunology and …

Inflammation is a multicomponent response to tissue stress, injury and infection, and a
crucial point of its control is at the level of gene transcription. The inducible inflammatory …

Macrophage activation is associated with profound transcriptional reprogramming. Although
much progress has been made in the understanding of macrophage activation, polarization …

Cellular RNA levels are determined by the interplay of RNA production, processing and
degradation. However, because most studies of RNA regulation do not distinguish the …

Biological processes are often dynamic, thus researchers must monitor their activity at
multiple time points. The most abundant source of information regarding such dynamic …

Social status is one of the strongest predictors of human disease risk and mortality, and it
also influences Darwinian fitness in social mammals more generally. To understand the …

Macrophages respond to inflammatory stimuli by modulating the expression of hundreds of
genes in a defined temporal cascade, with diverse transcriptional and posttranscriptional …

Models of mammalian regulatory networks controlling gene expression have been inferred
from genomic data but have largely not been validated. We present an unbiased strategy to …

High salt is positively associated with the risk of many diseases. However, little is known
about the mechanisms. Here we showed that high salt increased proinflammatory …

Many mechanisms contribute to regulation of gene expression to ensure coordinated
cellular behaviors and fate decisions. Transcriptional responses to external signals can …