Pharmacokinetics of magnetic iron oxide nanoparticles for medical applications
Magnetic iron oxide nanoparticles (MNPs) have been under intense investigation for at least
the last five decades as they show enormous potential for many biomedical applications …
the last five decades as they show enormous potential for many biomedical applications …
The repertoire of small-molecule PET probes for neuroinflammation imaging: challenges and opportunities beyond TSPO
Neuroinflammation is an adaptive response of the central nervous system to diverse
potentially injurious stimuli, which is closely associated with neurodegeneration and …
potentially injurious stimuli, which is closely associated with neurodegeneration and …
Molecular alterations of the endocannabinoid system in psychiatric disorders
D Navarro, A Gasparyan, F Navarrete… - International journal of …, 2022 - mdpi.com
The therapeutic benefits of the current medications for patients with psychiatric disorders
contrast with a great variety of adverse effects. The endocannabinoid system (ECS) …
contrast with a great variety of adverse effects. The endocannabinoid system (ECS) …
Evaluation of [18F]RoSMA-18-d6 as a CB2 PET Radioligand in Nonhuman Primates
The cannabinoid type 2 receptor (CB2) has been implicated in a variety of central and
peripheral inflammatory diseases, prompting significant interest in the development of CB2 …
peripheral inflammatory diseases, prompting significant interest in the development of CB2 …
Cannabidiol and neurodevelopmental disorders in children
Neurodevelopmental and neuropsychiatric disorders (such as autism spectrum disorder)
have broad health implications for children, with no definitive cure for the vast majority of …
have broad health implications for children, with no definitive cure for the vast majority of …
Translational Preclinical PET Imaging and Metabolic Evaluation of a New Cannabinoid 2 Receptor (CB2R) Radioligand, (Z)-N-(3-(2-(2-[18F]Fluoroethoxy)ethyl)-4,5 …
S Auvity, B Attili, F Caillé, M Goislard… - ACS Pharmacology & …, 2024 - ACS Publications
We have previously developed seven fluorinated analogues of A-836339 as new PET
tracers for cannabinoid type 2 receptor (CB2R) imaging, among which (Z)-N-(3-(2-(2-[18F] …
tracers for cannabinoid type 2 receptor (CB2R) imaging, among which (Z)-N-(3-(2-(2-[18F] …
Strategies for designing novel positron emission tomography (PET) radiotracers to cross the blood–brain barrier
Positron emission tomography (PET) is a powerful tool for imaging biological processes in
the central nervous system (CNS). Designing PET radiotracers capable of crossing the …
the central nervous system (CNS). Designing PET radiotracers capable of crossing the …
Non-invasive mass and temperature quantifications with spectral CT
Spectral CT has been increasingly implemented clinically for its better characterization and
quantification of materials through its multi-energy results. It also facilitates calculation of …
quantification of materials through its multi-energy results. It also facilitates calculation of …
Structure-Based Design, Optimization, and Development of [18F]LU13: A Novel Radioligand for Cannabinoid Receptor Type 2 Imaging in the Brain with PET
D Gündel, W Deuther-Conrad… - Journal of Medicinal …, 2022 - ACS Publications
The cannabinoid receptor type 2 (CB2R) is an attractive target for the diagnosis and therapy
of neurodegenerative diseases and cancer. In this study, we aimed at the development of a …
of neurodegenerative diseases and cancer. In this study, we aimed at the development of a …
Development of high brain-penetrant and reversible monoacylglycerol lipase PET tracers for neuroimaging
Monoacylglycerol lipase (MAGL) is one of the key enzymes in the endocannabinoid system.
Inhibition of MAGL has been proposed as an attractive approach for the treatment of various …
Inhibition of MAGL has been proposed as an attractive approach for the treatment of various …