Influences of crystal anisotropy in pharmaceutical process development

E Hadjittofis, MA Isbell, V Karde, S Varghese… - Pharmaceutical …, 2018 - Springer
Crystalline materials are of crucial importance to the pharmaceutical industry, as a large
number of APIs are formulated in crystalline form, occasionally in the presence of crystalline …

Development of renewable biomass-derived carbonaceous aerogel/mannitol phase-change composites for high thermal-energy-release efficiency and shape …

H Liu, Z Qian, Q Wang, D Wu… - ACS Applied Energy …, 2021 - ACS Publications
As a type of promising phase-change materials, sugar alcohols have a great potential for
thermal energy storage due to their high energy-storage density. However, the …

Specific surface area of mannitol rather than particle size dominant the dissolution rate of poorly water-soluble drug tablets: A study of binary mixture

K Zhang, S Qian, Z Liu, H Liu, Z Lin, W Heng… - International Journal of …, 2024 - Elsevier
The dissolution behavior of tablets, particularly those containing poorly water-soluble drugs,
is a critical factor in determining their absorption and therapeutic efficacy. Traditionally, the …

Relating crystal structure to surface properties: A study on quercetin solid forms

P Klitou, I Rosbottom, V Karde, JYY Heng… - Crystal Growth & …, 2022 - ACS Publications
The surface energy and surface chemistry of a crystal are of great importance when
designing particles for a specific application, as these will impact both downstream …

The role of the solid state and physical properties of the carrier in adhesive mixtures for lung delivery

A Della Bella, E Salomi, F Buttini… - Expert Opinion on Drug …, 2018 - Taylor & Francis
Introduction: Direct administration of drugs to the lung is commonly used for the treatment of
local respiratory diseases, but it can also be employed to obtain a systemic effect. Besides …

Co-delivery of D-LAK antimicrobial peptide and capreomycin as inhaled powder formulation to combat drug-resistant tuberculosis

Z Shao, MYT Chow, SF Chow, JKW Lam - Pharmaceutical Research, 2023 - Springer
Introduction The emergence of multidrug-resistant (MDR) Mycobacterium tuberculosis (Mtb)
posed a severe challenge to tuberculosis (TB) management. The treatment of MDR-TB …

Pulmonary delivery of spray-dried Nisin ZP antimicrobial peptide for non-small cell lung cancer (NSCLC) treatment

SM Patil, DS Barji, S Aziz, DA McChesney… - International Journal of …, 2023 - Elsevier
Nisin ZP is an antimicrobial peptide (AMP) produced by the bacterium Lactococcus lactis,
and we have previously demonstrated anticancer activity in NSCLC (A549) cells. In this …

Mannitol polymorphs as carrier in DPIs formulations: isolation characterization and performance

A Altay Benetti, A Bianchera, F Buttini, L Bertocchi… - Pharmaceutics, 2021 - mdpi.com
The search for best performing carriers for dry powder inhalers is getting a great deal of
interest to overcome the limitations posed by lactose. The aerosolization of adhesive …

Spray-dried powder formulation of capreomycin designed for inhaled tuberculosis therapy

Z Shao, W Tai, Y Qiu, RCH Man, Q Liao, MYT Chow… - Pharmaceutics, 2021 - mdpi.com
Multi-drug-resistant tuberculosis (MDR-TB) is a huge public health problem. The treatment
regimen of MDR-TB requires prolonged chemotherapy with multiple drugs including second …

Development of PEGylated chitosan/CRISPR-Cas9 dry powders for pulmonary delivery via thin-film freeze-drying

H Zhang, Y Zhang, RO Williams III… - International Journal of …, 2021 - Elsevier
Gene therapy and more recently, gene editing is attractive via pulmonary delivery for
enhanced regional targeting. However, processing of sensitive therapeutics into dry …