Finding the genomic basis of local adaptation: pitfalls, practical solutions, and future directions

S Hoban, JL Kelley, KE Lotterhos… - The American …, 2016 - journals.uchicago.edu
Uncovering the genetic and evolutionary basis of local adaptation is a major focus of
evolutionary biology. The recent development of cost-effective methods for obtaining high …

Common garden experiments in the genomic era: new perspectives and opportunities

P de Villemereuil, OE Gaggiotti, M Mouterde… - Heredity, 2016 - nature.com
The study of local adaptation is rendered difficult by many evolutionary confounding
phenomena (for example, genetic drift and demographic history). When complex traits are …

Comparing methods for detecting multilocus adaptation with multivariate genotype–environment associations

BR Forester, JR Lasky, HH Wagner… - Molecular …, 2018 - Wiley Online Library
Identifying adaptive loci can provide insight into the mechanisms underlying local
adaptation. Genotype–environment association (GEA) methods, which identify these loci …

pcadapt: an R package to perform genome scans for selection based on principal component analysis

K Luu, E Bazin, MGB Blum - Molecular ecology resources, 2017 - Wiley Online Library
The r package pcadapt performs genome scans to detect genes under selection based on
population genomic data. It assumes that candidate markers are outliers with respect to how …

Genome-wide scan for adaptive divergence and association with population-specific covariates

M Gautier - Genetics, 2015 - academic.oup.com
In population genomics studies, accounting for the neutral covariance structure across
population allele frequencies is critical to improve the robustness of genome-wide scan …

Evolutionary history and global spread of the Mycobacterium tuberculosis Bei**g lineage

M Merker, C Blin, S Mona, N Duforet-Frebourg… - Nature …, 2015 - nature.com
Mycobacterium tuberculosis strains of the Bei**g lineage are globally distributed and are
associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia …

The relative power of genome scans to detect local adaptation depends on sampling design and statistical method

KE Lotterhos, MC Whitlock - Molecular ecology, 2015 - Wiley Online Library
Although genome scans have become a popular approach towards understanding the
genetic basis of local adaptation, the field still does not have a firm grasp on how sampling …

Fast principal-component analysis reveals convergent evolution of ADH1B in Europe and East Asia

KJ Galinsky, G Bhatia, PR Loh, S Georgiev… - The American Journal of …, 2016 - cell.com
Searching for genetic variants with unusual differentiation between subpopulations is an
established approach for identifying signals of natural selection. However, existing methods …

[HTML][HTML] The genomics of human local adaptation

JS Rees, S Castellano, AM Andrés - Trends in Genetics, 2020 - cell.com
Modern humans inhabit a variety of environments and are exposed to a plethora of selective
pressures, leading to multiple genetic adaptations to local environmental conditions. These …

Using neutral, selected, and hitchhiker loci to assess connectivity of marine populations in the genomic era

PA Gagnaire, T Broquet, D Aurelle… - Evolutionary …, 2015 - Wiley Online Library
Estimating the rate of exchange of individuals among populations is a central concern to
evolutionary ecology and its applications to conservation and management. For instance …