Ferroptosis: mechanisms and links with diseases

H Yan, T Zou, QZ Tuo, S Xu, H Li, AA Belaidi… - Signal transduction and …, 2021 - nature.com
Ferroptosis is an iron-dependent cell death, which is different from apoptosis, necrosis,
autophagy, and other forms of cell death. The process of ferroptotic cell death is defined by …

Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion

JP Friedmann Angeli, DV Krysko, M Conrad - Nature Reviews Cancer, 2019 - nature.com
Ferroptosis is a recently recognized cell death modality that is morphologically,
biochemically and genetically distinct from other forms of cell death and that has emerged to …

Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death

AA Kapralov, Q Yang, HH Dar, YY Tyurina… - Nature chemical …, 2020 - nature.com
Ferroptotic death is the penalty for losing control over three processes—iron metabolism,
lipid peroxidation and thiol regulation—that are common in the pro-inflammatory …

Diversity of macrophages in lung homeostasis and diseases

F Hou, K **ao, L Tang, L **e - Frontiers in immunology, 2021 - frontiersin.org
Lung macrophages play important roles in the maintenance of homeostasis, pathogen
clearance and immune regulation. The different types of pulmonary macrophages and their …

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

VE Kagan, G Mao, F Qu, JPF Angeli, S Doll… - Nature chemical …, 2017 - nature.com
Enigmatic lipid peroxidation products have been claimed as the proximate executioners of
ferroptosis—a specialized death program triggered by insufficiency of glutathione …

Linking cellular stress responses to systemic homeostasis

L Galluzzi, T Yamazaki, G Kroemer - Nature Reviews Molecular Cell …, 2018 - nature.com
Mammalian cells respond to stress by activating mechanisms that support cellular functions
and hence maintain microenvironmental and organismal homeostasis. Intracellular …

The role of efferocytosis‐fueled macrophage metabolism in the resolution of inflammation

M Schilperoort, D Ngai, SR Sukka… - Immunological …, 2023 - Wiley Online Library
The phagocytosis of dying cells by macrophages, termed efferocytosis, is a tightly regulated
process that involves the sensing, binding, engulfment, and digestion of apoptotic cells …

Resolution of chronic inflammatory disease: universal and tissue-specific concepts

G Schett, MF Neurath - Nature communications, 2018 - nature.com
Inflammation and its resolution is under-studied in medicine despite being essential for
understanding the development of chronic inflammatory disease. In this review article, we …

Resolution of inflammation: a new therapeutic frontier

JN Fullerton, DW Gilroy - Nature reviews Drug discovery, 2016 - nature.com
Dysregulated inflammation is a central pathological process in diverse disease states.
Traditionally, therapeutic approaches have sought to modulate the pro-or anti-inflammatory …

[HTML][HTML] PEBP1 wardens ferroptosis by enabling lipoxygenase generation of lipid death signals

SE Wenzel, YY Tyurina, J Zhao, CMS Croix, HH Dar… - Cell, 2017 - cell.com
Ferroptosis is a form of programmed cell death that is pathogenic to several acute and
chronic diseases and executed via oxygenation of polyunsaturated …