The prevalence of obstructive sleep apnea (OSA) continues to rise. So too do the health,
safety, and economic consequences. On an individual level, the causes and consequences …

People develop obstructive sleep apnoea (OSA) for different reasons. The ability to
understand these reasons, easily identify them in individual patients, and develop therapies …

Rationale: The pathophysiologic causes of obstructive sleep apnea (OSA) likely vary among
patients but have not been well characterized. Objectives: To define carefully the proportion …

Background Evaluation and interpretation of the literature on obstructive sleep apnea (OSA)
allows for consolidation and determination of the key factors important for clinical …

OSA is a heterogeneous disorder. If left untreated, it has major health, safety, and economic
consequences. In addition to varying levels of impairment in pharyngeal anatomy …

Rationale: Therapies for obstructive sleep apnea (OSA) could be administered on the basis
of a patient's own phenotypic causes (“traits”) if a clinically applicable approach were …

Rationale: A low respiratory arousal threshold (ArTH) is one of several traits involved in
obstructive sleep apnea pathogenesis and may be a therapeutic target; however, there is no …

Traditionally, the presence and severity of obstructive sleep apnea (OSA) have been defined
by the apnea–hypopnea index (AHI). Continuous positive airway pressure is generally first …

Rationale: Oral appliances (OAs) are commonly used as an alternative treatment to
continuous positive airway pressure for patients with obstructive sleep apnea (OSA) …

Rationale: Current therapies for obstructive sleep apnea (OSA) are limited by insufficient
efficacy, compliance, or tolerability. An effective pharmacological treatment for OSA is …