The UDP-glycosyltransferase (UGT) superfamily: new members, new functions, and novel paradigms
UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …
Clinical pharmacokinetics and pharmacodynamics of mycophenolate in solid organ transplant recipients
This review aims to provide an extensive overview of the literature on the clinical
pharmacokinetics of mycophenolate in solid organ transplantation and a briefer summary of …
pharmacokinetics of mycophenolate in solid organ transplantation and a briefer summary of …
UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan
LE Carlini, NJ Meropol, J Bever, ML Andria, T Hill… - Clinical Cancer …, 2005 - AACR
Purpose: Capecitabine and irinotecan are commonly used in the treatment of metastatic
colorectal cancer (CRC). We hypothesized that germline polymorphisms within genes …
colorectal cancer (CRC). We hypothesized that germline polymorphisms within genes …
Predictive Role of the UGT1A1, UGT1A7, and UGT1A9 Genetic Variants and Their Haplotypes on the Outcome of Metastatic Colorectal Cancer Patients Treated …
E Cecchin, F Innocenti, M D'Andrea… - Journal of Clinical …, 2009 - ascopubs.org
Purpose UGT1A1★ 28 is considered the main pharmacogenetic predictor of the toxicity
outcome of irinotecan-treated patients. We evaluated the effect of other UGT1A variants and …
outcome of irinotecan-treated patients. We evaluated the effect of other UGT1A variants and …
[HTML][HTML] Pharmacogenetics of the systemic treatment in advanced hepatocellular carcinoma
Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers. To date,
most patients with HCC are diagnosed at an advanced tumor stage, excluding them from …
most patients with HCC are diagnosed at an advanced tumor stage, excluding them from …
The role of organic anion–transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics
The goal of this study was to determine the roles of the organic anion–transporting
polypeptides (OATPs) OATP1A2, OATP1B1, and OATP1B3 and their genetic variants in the …
polypeptides (OATPs) OATP1A2, OATP1B1, and OATP1B3 and their genetic variants in the …
Transcriptional regulation of human UDP-glucuronosyltransferase genes
Glucuronidation is an important metabolic pathway for many small endogenous and
exogenous lipophilic compounds, including bilirubin, steroid hormones, bile acids …
exogenous lipophilic compounds, including bilirubin, steroid hormones, bile acids …
The impact of uridine diphosphate–glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single‐nucleotide polymorphisms T—275A and C—2152T on …
DRJ Kuypers, M Naesens, S Vermeire… - Clinical …, 2005 - Wiley Online Library
Background Mycophenolic acid (MPA), an effective immunosuppressive drug used in renal
transplantation, is extensively glucuronidated by several uridine diphosphate …
transplantation, is extensively glucuronidated by several uridine diphosphate …
Mycophenolate, clinical pharmacokinetics, formulations, and methods for assessing drug exposure
This article summarizes part of a consensus meeting about mycophenolate (MPA)
therapeutic drug monitoring held in Rome under the auspices of The Transplantation …
therapeutic drug monitoring held in Rome under the auspices of The Transplantation …
The impact of UGT1A8, UGT1A9, and UGT2B7 genetic polymorphisms on the pharmacokinetic profile of mycophenolic acid after a single oral dose in healthy …
E Levesque, R Delage… - Clinical …, 2007 - Wiley Online Library
We studied whether polymorphisms in the UGT1A8, UGT1A9, and UGT2B7 genes, the
enzymes producing the phenolic (MPAG) and acyl (AcMPAG) glucuronides of mycophenolic …
enzymes producing the phenolic (MPAG) and acyl (AcMPAG) glucuronides of mycophenolic …