Abstract Tumor Necrosis Factor (TNF), initially known for its tumor cytotoxicity, is a potent
mediator of inflammation, as well as many normal physiological functions in homeostasis …

Evasion of apoptosis is considered to be one of the hallmarks of human cancers. This cell
death modality is executed by caspases and several upstream regulatory factors, which …

Mutations affecting RNA splicing factors are the most common genetic alterations in
myelodysplastic syndrome (MDS) patients and occur in a mutually exclusive manner. The …

TRAIL is a potent inducer of apoptosis and has been studied almost exclusively in this
context. However, TRAIL can also induce NFκB-dependent expression of multiple pro …

Abstract Cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein (c-FLIP) is a
master anti-apoptotic regulator and resistance factor that suppresses tumor necrosis factor-α …

During the course of an immune response, antigen-reactive T cells clonally expand and then
are removed by apoptosis to maintain immune homeostasis. Life and death of T cells is …

During their lifetime, cells encounter many life or death situations that challenge their very
own existence. Their survival depends on the interplay within a complex yet precisely …

Caspases, a family of evolutionarily, conserved cysteinyl proteases, mediate both apoptosis
and inflammation through aspartate-specific cleavage of a wide number of cellular …

The nuclear factor (NF)-κB family of eukaryotic transcription factors plays an important role in
the regulation of immune response, embryo and cell lineage development, cell apoptosis …

Upon stimulation, CD95 (APO-1/Fas) recruits the adapter molecule FADD/MORT1,
procaspase-8, and the cellular FLICE-inhibitory proteins (c-FLIP) into the death-inducing …