Vitiligo is an autoimmune skin disorder caused by dysfunctional pigment-producing
melanocytes which are attacked by immune cells. Oxidative stress is considered to play a …

Gene therapy is one of the most advanced therapies in current medicine. In particular,
interference RNA-based therapy by small interfering RNA (siRNA) has gained attention in …

Vitiligo is a complex disease wherein derangements in multiple pathways determine the loss
of functional melanocytes. Since its pathogenesis is not yet completely understood, vitiligo …

The skin epidermis is continually influenced by a myriad of internal and external elements.
At its basal layer reside epidermal stem cells, which fuels epidermal renovation and hair …

Vitiligo is a complex disorder with an important effect on the self-esteem and social life of
patients. It is the commonest acquired depigmentation disorder characterized by the …

Vitiligo is a common acquired pigmentary disorder that presents as progressive loss of
melanocytes from the skin. Epidermal melanocytes and keratinocytes are in close proximity …

Tyrosinase (TYR) functions as the critical enzyme in biosynthesis of melanin, and its
abnormality is an important hallmark for skin pigmentary disorders. This renders the …

Background Vitiligo is an autoimmune skin disorder characterized by loss of melanocytes.
Protease-mediated disruption of junctions between keratinocytes and/or keratinocyte …

The basement membrane zone is the interface between the epidermis and dermis, and it is
disrupted in several skin conditions. Here, we report the results of a comprehensive …

Vitiligo is an autoimmune disease that leads to disfiguring depigmented lesions of skin and
mucosa. Although effective treatments are available for vitiligo, there are still some patients …