Human red blood cells (RBC) are highly differentiated cells that have lost all organelles and
most intracellular machineries during their maturation process. RBC are fundamental for the …

Platelets are small anucleate cellular fragments that are released by megakaryocytes and
safeguard vascular integrity through a process termed 'haemostasis'. However, platelets …

Chitosans are versatile biopolymers with multiple biological activities and potential
applications. They are linear copolymers of glucosamine and N-acetylglucosamine defined …

Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), also known as coronavirus
disease 2019 (COVID-19)-induced infection, is strongly associated with various …

The microenvironment of malignant melanomas defines the properties of tumor blood
vessels and regulates infiltration and vascular dissemination of immune and cancer cells …

Endothelial cells, located on the surface of blood vessel walls, are constantly stimulated by
mechanical forces from the blood flow. The mechanical forces, ie, fluid shear stress, induced …

von Willebrand factor (VWF) and platelets are key mediators of normal hemostasis. At sites
of vascular injury, VWF recruits platelets via binding to the platelet receptor glycoprotein Ibα …

ADAMTS13, a metalloproteinase, specifically cleaves unusually large multimers of von
Willebrand factor (VWF), newly released from vascular endothelial cells. The ratio of …

Platelet adhesion and activation are essential initial processes of arterial and microvascular
hemostasis, where high hydrodynamic forces from the bloodflow impede coagulation. The …

It has been confirmed that platelets play a key role in tumorigenesis. Tumor-activated
platelets can recruit blood cells and immune cells to migrate, establish an inflammatory …