Scaffolds for drug delivery and tissue engineering: The role of genetics

A Zielińska, J Karczewski, P Eder… - … Clinics and Research, 2023 - journals.lww.com
Scaffolds are implants commonly used to deliver cells, drugs, and genes into the body. Their
regular porous structure ensures the proper support for cell attachment, proliferation …

Advanced postoperative tissue antiadhesive membranes enabled with electrospun nanofibers

Y Zhu, C Zhang, Y Liang, J Shi, Q Yu, S Liu, D Yu… - Biomaterials …, 2024 - pubs.rsc.org
Tissue adhesion is one of the most common postoperative complications, which is frequently
accompanied by inflammation, pain, and even dyskinesia, significantly reducing the quality …

Self‐healing hydrogel embodied with macrophage‐regulation and responsive‐gene‐silencing properties for synergistic prevention of peritendinous adhesion

C Cai, X Zhang, Y Li, X Liu, S Wang, M Lu… - Advanced …, 2022 - Wiley Online Library
Antiadhesion barriers such as films and hydrogels used to wrap repaired tendons are
important for preventing the formation of adhesion tissue after tendon surgery. However …

Peritoneum‐inspired Janus porous hydrogel with anti‐deformation, anti‐adhesion, and pro‐healing characteristics for abdominal wall defect treatment

W Liang, W He, R Huang, Y Tang, S Li… - Advanced …, 2022 - Wiley Online Library
Implantable meshes used in tension‐free repair operations facilitate treatment of internal soft‐
tissue defects. However, clinical meshes fail to achieve anti‐deformation, anti‐adhesion …

Rejuvenation of tendon stem/progenitor cells for functional tendon regeneration through platelet-derived exosomes loaded with recombinant Yap1

J Lu, X Yang, C He, Y Chen, C Li, S Li, Y Chen, Y Wu… - Acta Biomaterialia, 2023 - Elsevier
The regenerative capabilities including self-renewal, migration and differentiation potentials
shift from the embryonic phase to the mature period of endogenous tendon stem/progenitor …

Instantaneous self-healing and strongly adhesive self-adaptive hyaluronic acid-based hydrogel for controlled drug release to promote tendon wound healing

Z Ren, Z Duan, Z Zhang, R Fu, C Zhu, D Fan - International Journal of …, 2023 - Elsevier
The treatment of tendon injuries is an important healthcare challenge. Irregular wounds,
hypocellularity, and prolonged inflammation impede the rate of healing for tendon injuries …

Functional biomaterials for tendon/ligament repair and regeneration

Y Tang, Z Wang, L **ang, Z Zhao… - Regenerative …, 2022 - academic.oup.com
With an increase in life expectancy and the popularity of high-intensity exercise, the
frequency of tendon and ligament injuries has also increased. Owing to the specificity of its …

Self-assembling peptide hydrogels as functional tools to tackle intervertebral disc degeneration

C Ligorio, JA Hoyland, A Saiani - Gels, 2022 - mdpi.com
Low back pain (LBP), caused by intervertebral disc (IVD) degeneration, is a major
contributor to global disability. In its healthy state, the IVD is a tough and well-hydrated …

[HTML][HTML] TGF-β3-loaded graphene oxide-self-assembling peptide hybrid hydrogels as functional 3D scaffolds for the regeneration of the nucleus pulposus

C Ligorio, M O'Brien, NW Hodson, A Mironov, M Iliut… - Acta biomaterialia, 2021 - Elsevier
Intervertebral disc (IVD) degeneration is a process that starts in the central nucleus pulposus
(NP) and leads to inflammation, extracellular matrix (ECM) degradation, and progressive …

[HTML][HTML] Piezoelectrically-enhanced composite membranes mimicking the tendinous electrical microenvironment for advanced tendon repair

W Wang, P Wang, Q Li, W Dai, B Yi, Z Gao, W Liu… - Nano Today, 2024 - Elsevier
Tendon injuries, prevalent in clinical settings, predominantly arise from the disruption of the
collagen matrix and are typically accompanied by pronounced inflammatory responses and …