Transcription factors play an indispensable role in maintaining cellular viability and finely
regulating complex internal metabolic networks. These crucial bioactive functions rely on …

Covering: up to the end of July, 2021 Anthraquinone-fused enediynes (AFEs) are a
subfamily of enediyne natural products. Dynemicin A (DYN A), the first member of the AFE …

Transcription activation is established through extensive protein–protein and protein–DNA
interactions that allow an activator to engage and remodel RNA polymerase. SoxS, a global …

Rob, which serves as a paradigm of the large AraC/XylS family transcription activators,
regulates diverse subsets of genes involved in multidrug resistance and stress response …

The emergence and propagation of bacteria resistant to antimicrobial drugs is a serious
public health threat worldwide. The current antibacterial arsenal is becoming obsolete, and …

Shigella, the aetiological agent of human bacillary dysentery, controls the expression of its
virulence determinants through an environmentally stimulated cascade of transcriptional …

Fine-tuning gene expression is of great interest for synthetic biotechnological applications.
This is particularly true for the genus Streptomyces, which is well-known as a prolific …

The pathogenicity of Shigella, the intracellular pathogen responsible for human bacillary
dysentery, depends on a coordinated and tightly regulated expression of its virulence …

Vibrio parahaemolyticus (Vpar) is a major cause of seafood-related gastroenteritis. A
pandemic strain, RIMD2210633 (RIMD), has emerged from ancestors due to virulence …

The multiple-sugar metabolism regulator (MsmR), a transcription factor belonging to the
AraC/XylS family, participates in polysaccharide metabolism and virulence. However, the …