Emerging biomarkers in autism spectrum disorder: a systematic review

RE Frye, S Vassall, G Kaur, C Lewis… - Annals of …, 2019 - pmc.ncbi.nlm.nih.gov
Autism spectrum disorder (ASD) affects approximately 2% of children in the United States
(US) yet its etiology is unclear and effective treatments are lacking. Therapeutic interventions …

Recent advances in autism research as reflected in DSM-5 criteria for autism spectrum disorder

C Lord, SL Bishop - Annual review of clinical psychology, 2015 - annualreviews.org
This article provides a selective review of advances in scientific knowledge about autism
spectrum disorder (ASD), using DSM-5 (Diagnostic and Statistical Manual of Mental …

[HTML][HTML] Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease

M **, R Xu, L Wang, MM Alam, Z Ma, S Zhu… - Cell Stem Cell, 2022 - cell.com
Microglia are critical in brain development and Alzheimer's disease (AD) etiology. Down
syndrome (DS) is the most common genetic developmental disorder and risk factor for AD …

Prevalence of autism and attention‐deficit–hyperactivity disorder in Down syndrome: a population‐based study

UW Oxelgren, Å Myrelid, G Annerén… - … Medicine & Child …, 2017 - Wiley Online Library
Aim To investigate the prevalence of autism spectrum disorder (ASD) and attention‐deficit–
hyperactivity disorder (ADHD) in a population‐based group of children and adolescents with …

Language and speech in autism

MA Gernsbacher, EM Morson… - Annual review of …, 2016 - annualreviews.org
Autism is a developmental disability characterized by atypical social interaction, interests or
body movements, and communication. Our review examines the empirical status of three …

Metabolomics analysis of children with autism, idiopathic-developmental delays, and Down syndrome

JS Orozco, I Hertz-Picciotto, L Abbeduto… - Translational …, 2019 - nature.com
Although developmental delays affect learning, language, and behavior, some evidence
suggests the presence of disturbances in metabolism are associated with psychiatric …

Opportunities, barriers, and recommendations in Down syndrome research

JA Hendrix, A Amon, L Abbeduto… - … science of rare …, 2021 - journals.sagepub.com
BACKGROUND: Recent advances in medical care have increased life expectancy and
improved the quality of life for people with Down syndrome (DS). These advances are the …

Early infant development and intervention for autism spectrum disorder

LAR Sacrey, JA Bennett… - Journal of child …, 2015 - journals.sagepub.com
Objective: The objective is to overview recent findings on early detection/diagnosis of autism
spectrum disorders, as well as clinical trials of early interventions for toddlers at risk …

Neurologic complications of Down syndrome: a systematic review

JD Santoro, D Pagarkar, DT Chu, M Rosso… - Journal of …, 2021 - Springer
Down syndrome (DS) is one of the most well-recognized genetic disorders. Persons with DS
are known to have a variety of co-morbid medical problems, affecting nearly all organ …

Heterogeneity of autism characteristics in genetic syndromes: key considerations for assessment and support

L Jenner, C Richards, R Howard, J Moss - Current developmental …, 2023 - Springer
Abstract Purpose of Review Elevated prevalence of autism characteristics is reported in
genetic syndromes associated with intellectual disability. This review summarises recent …