There is a growing attention toward personalized medicine. This is led by a fundamental
shift from the 'one size fits all'paradigm for treatment of patients with conditions or …

Mendelian and complex genetic trait diseases continue to burden and affect society both
socially and economically. The lack of effective tests has hampered diagnosis thus, the …

The rise of technologies that simultaneously measure thousands of data points represents
the heart of systems biology. These technologies have had a huge impact on the discovery …

Variants within non-coding genomic regions can greatly affect disease. In recent years,
increasing focus has been given to these variants, and how they can alter regulatory …

Sequencing has revolutionized biology by permitting the analysis of genomic variation at an
unprecedented resolution. High-throughput sequencing is fast and inexpensive, making it …

Massive data produced due to the advent of next-generation sequencing (NGS) technology
is widely used for biological researches and medical diagnosis. The crucial step in NGS …

Context.—Next-generation sequencing (NGS) is revolutionizing the discipline of laboratory
medicine, with a deep and direct impact on patient care. Although it empowers clinical …

High-throughput sequencing technologies have rapidly developed during the past years
and have become an essential tool in plant sciences. However, the analysis of genomic data …

DNA methylation is associated with transcriptional repression, genomic imprinting, stem cell
differentiation, embryonic development, and inflammation. Aberrant DNA methylation can …

Genomic alignment of small RNA (smRNA) sequences such as microRNAs poses
considerable challenges due to their short length (∼ 21 nucleotides [nt]) as well as the large …