Clinical application and detection techniques of liquid biopsy in gastric cancer

S Ma, M Zhou, Y Xu, X Gu, M Zou, G Abudushalamu… - Molecular Cancer, 2023 - Springer
Gastric cancer (GC) is one of the most common tumors worldwide and the leading cause of
tumor-related mortality. Endoscopy and serological tumor marker testing are currently the …

Circulating tumor cells: approaches to isolation and characterization

M Yu, S Stott, M Toner, S Maheswaran… - Journal of Cell …, 2011 - rupress.org
Circulating tumor cells (CTCs) shed from primary and metastatic cancers are admixed with
blood components and are thus rare, making their isolation and characterization a major …

Microfluidic, marker-free isolation of circulating tumor cells from blood samples

NM Karabacak, PS Spuhler, F Fachin, EJ Lim, V Pai… - Nature protocols, 2014 - nature.com
The ability to isolate and analyze rare circulating tumor cells (CTCs) has the potential to
further our understanding of cancer metastasis and enhance the care of cancer patients. In …

Label-free cell separation and sorting in microfluidic systems

DR Gossett, WM Weaver, AJ Mach, SC Hur… - Analytical and …, 2010 - Springer
Cell separation and sorting are essential steps in cell biology research and in many
diagnostic and therapeutic methods. Recently, there has been interest in methods which …

Isolation and retrieval of circulating tumor cells using centrifugal forces

HW Hou, ME Warkiani, BL Khoo, ZR Li, RA Soo… - Scientific reports, 2013 - nature.com
Presence and frequency of rare circulating tumor cells (CTCs) in bloodstreams of cancer
patients are pivotal to early cancer detection and treatment monitoring. Here, we use a spiral …

Blood-based analyses of cancer: circulating tumor cells and circulating tumor DNA

DA Haber, VE Velculescu - Cancer discovery, 2014 - AACR
The ability to study nonhematologic cancers through noninvasive sampling of blood is one
of the most exciting and rapidly advancing fields in cancer diagnostics. This has been driven …

Detection, clinical relevance and specific biological properties of disseminating tumour cells

K Pantel, RH Brakenhoff, B Brandt - Nature Reviews Cancer, 2008 - nature.com
Most cancer deaths are caused by haematogenous metastatic spread and subsequent
growth of tumour cells at distant organs. Disseminating tumour cells present in the …

Biomedical applications of microfluidic devices: a review

G Gharib, İ Bütün, Z Muganlı, G Kozalak, İ Namlı… - Biosensors, 2022 - mdpi.com
Both passive and active microfluidic chips are used in many biomedical and chemical
applications to support fluid mixing, particle manipulations, and signal detection. Passive …

Circulating tumour cells in cancer patients: challenges and perspectives

K Pantel, C Alix-Panabières - Trends in molecular medicine, 2010 - cell.com
Ultrasensitive methods have been recently developed to detect circulating tumour cells
(CTCs) in the peripheral blood and disseminated tumour cells (DTCs) in the bone marrow …

Size-selective collection of circulating tumor cells using Vortex technology

E Sollier, DE Go, J Che, DR Gossett, S O'Byrne… - Lab on a Chip, 2014 - pubs.rsc.org
A blood-based, low cost alternative to radiation intensive CT and PET imaging is critically
needed for cancer prognosis and management of its treatment.“Liquid biopsies” of …