ABSTRACT A milestone in the field of recombinant binding molecules was achieved 30
years ago with the discovery of single-domain antibodies from which antigen-binding …

Targeted protein degradation (TPD) is emerging as one of the most innovative strategies to
tackle infectious diseases. Particularly, proteolysis-targeting chimera (PROTAC)-mediated …

Kinetochores form the interface between chromosomes and spindle microtubules and are
thus under tight control by a complex regulatory circuitry. The Aurora B kinase plays a …

Nuclear RNA binding proteins (RBPs) are difficult to study because they often belong to
large protein families and form extensive networks of auto-and crossregulation. They are …

African trypanosomiasis (AT) is a hemoparasitic disease caused by infection with African
trypanosomes and it is prevalent in many sub-Saharan African countries, affecting both …

Accurate chromosome segregation during mitosis requires that all chromosomes establish
stable bi-oriented attachments with the spindle apparatus. Kinetochores form the interface …

Nuclear RNA binding proteins (RBPs) are difficult to study because they often belong to
large protein families and form extensive networks of auto-and cross-regulation. They are …

The Rab family of small GTPases are regulators of intracellular membrane trafficking.
Rab2B, a Golgi-resident Rab GTPase, has been shown to function in ER-Golgi transport and …