With the increase of population aging, the number of Alzheimer's disease (AD) patients is
also increasing. According to current estimates, approximately 11% of people over 65 suffer …

This article provides a contemporary review and a new perspective on the role of neprilysin
inhibition in heart failure (HF) in the context of recent clinical trials and addresses potential …

Alzheimer's disease (AD) is a degenerative neurological condition that gradually impairs
cognitive abilities, disrupts memory retention, and impedes daily functioning by impacting …

Alzheimer's disease (AD) is a heterogeneous neurodegenerative disease with multifaceted
neuropathological disorders. AD is characterized by intracellular accumulation of …

Abstract Angiotensin-converting enzyme-2, or ACE2, is primarily a zinc-dependent
peptidase and ectoenzyme expressed in numerous cell types and functioning as a …

Cardiovascular diseases have become a major clinical burden globally. Heart failure is one
of the diseases that commonly emanates from progressive uncontrolled hypertension. This …

Neprilysin (NEP) is a transmembrane zinc‐dependent metalloproteinase that inactivates
various peptide hormones including glucagon‐like peptide 1 (GLP‐1). NEP inhibitors may …

Nowadays, epigenetics is of great research value as a new gateway that can solve the
sophisticated mysteries behind neurodegenerative diseases. Epigenetic mechanisms …

Angiotensin-converting enzyme (ACE) is a zinc-dependent dipeptidyl carboxypeptidase and
is crucial in the renin-angiotensin-aldosterone system (RAAS) but also implicated in immune …

Decades of research have demonstrated an incontrovertible role of amyloid-β (Aβ) in the
etiology of Alzheimer's disease (AD). However, the overemphasis on the pathological …