The role of fractional calculus in modeling biological phenomena: A review
This review provides the latest developments and trends in the application of fractional
calculus (FC) in biomedicine and biology. Nature has often showed to follow rather simple …
calculus (FC) in biomedicine and biology. Nature has often showed to follow rather simple …
An optimal predictive control strategy for COVID-19 (SARS-CoV-2) social distancing policies in Brazil
This paper formulates a Model Predictive Control (MPC) policy to mitigate the COVID-19
contagion in Brazil, designed as optimal On-Off social isolation strategy. The proposed …
contagion in Brazil, designed as optimal On-Off social isolation strategy. The proposed …
An open source patient simulator for design and evaluation of computer based multiple drug dosing control for anesthetic and hemodynamic variables
We are witnessing a notable rise in the translational use of information technology and
control systems engineering tools in clinical practice. This paper empowers the computer …
control systems engineering tools in clinical practice. This paper empowers the computer …
Optimized PID control of depth of hypnosis in anesthesia
Abstract Background and Objective: This paper addresses the use of proportional-integral-
derivative controllers for regulating the depth of hypnosis in anesthesia by using propofol …
derivative controllers for regulating the depth of hypnosis in anesthesia by using propofol …
Fractional calculus in pharmacokinetics
We are witnessing the birth of a new variety of pharmacokinetics where non-integer-order
differential equations are employed to study the time course of drugs in the body: this is …
differential equations are employed to study the time course of drugs in the body: this is …
Closed-loop control of anesthesia: a primer for anesthesiologists
Although a number of experimental systems for closedloop control of anesthesia have been
reported, there are no clinical systems available today. However, if such systems are ever to …
reported, there are no clinical systems available today. However, if such systems are ever to …
Advanced model-based control studies for the induction and maintenance of intravenous anaesthesia
This paper describes strategies toward model-based automation of intravenous anaesthesia
employing advanced control techniques. In particular, based on a detailed compartmental …
employing advanced control techniques. In particular, based on a detailed compartmental …
Model predictive control using MISO approach for drug co-administration in anesthesia
In this paper, a model predictive control system for the depth of hypnosis is proposed and
analyzed. This approach considers simultaneous co-administration of the hypnotic and …
analyzed. This approach considers simultaneous co-administration of the hypnotic and …
Physiological closed-loop control (PCLC) systems: Review of a modern frontier in automation
Over the past decade, there has been an unprecedented international focus on improved
quality and availability of medical care, which has reignited interest in clinical automation …
quality and availability of medical care, which has reignited interest in clinical automation …
A comparison of propofol-to-BIS post-operative intensive care sedation by means of target controlled infusion, Bayesian-based and predictive control methods: an …
M Neckebroek, CM Ionescu, K Van Amsterdam… - Journal of Clinical …, 2019 - Springer
Purpose We evaluated the feasibility and robustness of three methods for propofol-to-
bispectral index (BIS) post-operative intensive care sedation, a manually-adapted target …
bispectral index (BIS) post-operative intensive care sedation, a manually-adapted target …