Cancer therapy with antibodies

S Paul, MF Konig, DM Pardoll, C Bettegowda… - Nature Reviews …, 2024 - nature.com
The greatest challenge in cancer therapy is to eradicate cancer cells with minimal damage
to normal cells. Targeted therapy has been developed to meet that challenge, showing a …

Single B cell technologies for monoclonal antibody discovery

A Pedrioli, A Oxenius - Trends in immunology, 2021 - cell.com
Monoclonal antibodies (mAbs) are often selected from antigen-specific single B cells
derived from different hosts, which are notably short-lived in ex vivo culture conditions and …

Hybridoma technology; advancements, clinical significance, and future aspects

S Mitra, PC Tomar - Journal of Genetic Engineering and Biotechnology, 2021 - Springer
Background Hybridoma technology is one of the most common methods used to produce
monoclonal antibodies. In this process, antibody-producing B lymphocytes are isolated from …

High-throughput spatiotemporal monitoring of single-cell secretions via plasmonic microwell arrays

S Ansaryan, YC Liu, X Li, AM Economou… - Nature biomedical …, 2023 - nature.com
Methods for the analysis of cell secretions at the single-cell level only provide
semiquantitative endpoint readouts. Here we describe a microwell array for the real-time …

Production of monoclonal antibodies for therapeutic purposes: A review

WP Alejandra, JPM Irene, GSF Antonio… - International …, 2023 - Elsevier
Monoclonal antibodies (mAbs) have been used in the development of immunotherapies that
target a variety of diseases, such as cancer, autoimmune diseases, and even viral infections; …

An overview on display systems (phage, bacterial, and yeast display) for production of anticancer antibodies; advantages and disadvantages

SZB Mahdavi, F Oroojalian, S Eyvazi, M Hejazi… - International Journal of …, 2022 - Elsevier
Antibodies as ideal therapeutic and diagnostic molecules are among the top-selling drugs
providing considerable efficacy in disease treatment, especially in cancer therapy …

Bismuth-213 for targeted radionuclide therapy: from atom to bedside

S Ahenkorah, I Cassells, CM Deroose, T Cardinaels… - Pharmaceutics, 2021 - mdpi.com
In contrast to external high energy photon or proton therapy, targeted radionuclide therapy
(TRNT) is a systemic cancer treatment allowing targeted irradiation of a primary tumor and …

[HTML][HTML] Principles and current clinical landscape of multispecific antibodies against cancer

M Elshiaty, H Schindler, P Christopoulos - International journal of …, 2021 - mdpi.com
Building upon the resounding therapeutic success of monoclonal antibodies, and supported
by accelerating progress in engineering methods, the field of multispecific therapeutic …

Inhalation monoclonal antibody therapy: a new way to treat and manage respiratory infections

HA Parray, S Shukla, R Perween, R Khatri… - Applied microbiology …, 2021 - Springer
The route of administration of a therapeutic agent has a substantial impact on its success.
Therapeutic antibodies are usually administered systemically, either directly by intravenous …

Advanced green analytical chemistry for environmental pesticide detection

N Kaur, A Khunger, SL Wallen, A Kaushik… - Current Opinion in …, 2021 - Elsevier
Highlights•Inevitable usage of pesticides poses a great threat to eco-system and food
safety.•Green analytical techniques are eco-affordable and can perform on-site pesticide …