Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Arthrofibrosis is a fibrotic joint disorder that begins with an inflammatory reaction to insults
such as injury, surgery and infection. Excessive extracellular matrix and adhesions contract …

Abstract N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6-PPDQ), a
transformation product of tyre-derived 6-PPD, has been frequently detected in different …

Increased levels of tumor necrosis factor (TNF) α have been linked to a number of
pulmonary inflammatory diseases including asthma, chronic obstructive pulmonary disease …

Ionizing radiation (IR) activates both pro-and anti-proliferative signal pathways producing an
imbalance in cell fate decision. IR is able to regulate several genes and factors involved in …

Burns and other traumatic injuries represent a substantial biomedical burden. The current
standard of care for deep injuries is autologous split-thickness skin grafting (STSG), which …

Fibrosis is the result of extracellular matrix protein deposition and remains a leading cause
of death in USA. Despite major advances in recent years, there remains an unmet need to …

Radiation-induced lung fibrosis (RILF) is a severe side effect of radiotherapy in lung cancer
patients that presents as a progressive pulmonary injury combined with chronic …

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic form of diffuse lung
disease occurring mainly in older adults. Increased lysophosphatidic acid (LPA) …

Pulmonary fibrosis represents the end stage of a number of heterogeneous conditions and
is, to a greater or lesser degree, the hallmark of the interstitial lung diseases. It is …