Leprosy, a disease caused by the intracellular parasite Mycobacterium leprae or
Mycobacterium lepromatosis, has affected humans for more than 4,000 years and is a …

Leprosy is a chronic infectious disease caused by Mycobacterium leprae. According to
official reports from 121 countries across five WHO regions, there were 213 899 newly …

Background Depending on the epidemiological setting, a variable proportion of leprosy
patients will suffer from excessive pro-inflammatory responses, termed type-1 reactions …

Leprosy is a chronic infectious disease of the skin and peripheral nerves that presents a
strong link with the host genetic background. Different approaches in genetic studies have …

Type-1 reactions (T1R) are pathological inflammatory episodes and main contributors to
nerve damage in leprosy. Here, we evaluate the genewise enrichment of rare protein …

Mycobacterium tuberculosis infection (Mtb) is the leading cause of death due to a single
infectious agent and is among the top ten causes of all human deaths worldwide. CD4 T …

Leprosy reactions are acute inflammatory episodes that complicate the course of a
Mycobacterium leprae infection and are the major cause of leprosy-associated pathology …

Since the leprosy cases have fallen dramatically, the incidence of leprosy has remained
stable over the past years, indicating that multidrug therapy seems unable to eradicate …

Genome-wide association studies (GWASs) have revealed the worldwide heterogeneity of
genetic factors in tuberculosis (TB) susceptibility. Despite having the third highest global TB …

The pathways that trigger exacerbated immune reactions in leprosy could be determined by
genetic variations. Here, in a prospective approach, both genetic and non-genetic variables …