Tissue inhibitors of metalloproteinases (TIMPs) are widely distributed in the animal kingdom
and the human genome contains four paralogous genes encoding TIMPs 1 to 4. TIMPs were …

Age related macular degeneration (AMD) is the leading cause of vision loss of those over
the age of 65 in the industrialized world. The prevalence and need to develop effective …

Age-related macular degeneration (AMD) and related macular dystrophies (MDs) are a
major cause of vision loss. However, the mechanisms underlying their progression remain ill …

The inherited macular dystrophies comprise a heterogeneous group of disorders
characterised by central visual loss and atrophy of the macula and underlying retinal …

Hereditary cone disorders (CDs) are characterized by defects of the cone photoreceptors or
retinal pigment epithelium underlying the macula, and include achromatopsia (ACHM), cone …

The central retina mediates high acuity vision, and its progressive dysfunction due to
macular degeneration is the leading cause of visual disability among adults in industrialized …

In response to cell swelling, volume-regulated anion channels (VRACs) participate in a
process known as regulatory volume decrease (RVD). Only recently, first insight into the …

purpose. Senescent Ccl2−/− mice are reported to develop cardinal features of human age-
related macular degeneration (AMD). Loss-of-function single-nucleotide polymorphisms …

Age-related macular degeneration (AMD) is the most prevalent form of irreversible blindness
worldwide in the elderly population. The pathology of dry AMD consists of macular …

Age-related macular degeneration (AMD) is a major leading cause of irreversible visual
impairment in the world with limited therapeutic interventions. Histological, biochemical …