Ferroptosis: mechanisms, biology and role in disease

X Jiang, BR Stockwell, M Conrad - Nature reviews Molecular cell …, 2021 - nature.com
The research field of ferroptosis has seen exponential growth over the past few years, since
the term was coined in 2012. This unique modality of cell death, driven by iron-dependent …

Regulation of lipid peroxidation and ferroptosis in diverse species

M Conrad, VE Kagan, H Bayir… - Genes & …, 2018 - genesdev.cshlp.org
Lipid peroxidation is the process by which oxygen combines with lipids to generate lipid
hydroperoxides via intermediate formation of peroxyl radicals. Vitamin E and coenzyme Q …

[HTML][HTML] Specialized pro-resolving mediators: endogenous regulators of infection and inflammation

MC Basil, BD Levy - Nature Reviews Immunology, 2016 - nature.com
Specialized pro-resolving mediators (SPMs) are enzymatically derived from essential fatty
acids and have important roles in orchestrating the resolution of tissue inflammation—that is …

Neutrophil function: from mechanisms to disease

B Amulic, C Cazalet, GL Hayes… - Annual review of …, 2012 - annualreviews.org
Neutrophils are the most abundant white blood cells in circulation, and patients with
congenital neutrophil deficiencies suffer from severe infections that are often fatal …

[HTML][HTML] Ferroptosis as an emerging target in inflammatory diseases

H Mao, Y Zhao, H Li, L Lei - Progress in biophysics and molecular biology, 2020 - Elsevier
Cell survival or death is one critical issue in inflammatory responses. Ferroptosis, which is
characterized by iron-dependent lethal lipid peroxidation, has been found to participate in …

Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators

CN Serhan, N Chiang, TE Van Dyke - Nature Reviews Immunology, 2008 - nature.com
Active resolution of acute inflammation is a previously unrecognized interface between
innate and adaptive immunity. Once thought to be a passive process, the resolution of …

Ferroptosis: From regulation of lipid peroxidation to the treatment of diseases

Y Lv, M Wu, Z Wang, J Wang - Cell Biology and Toxicology, 2023 - Springer
Ferroptosis is a regulated cell death mainly manifested by iron-dependent lipid peroxide
accumulation. The leading cause of ferroptosis is the imbalance of intracellular oxidative …

[HTML][HTML] Novel lipid mediators and resolution mechanisms in acute inflammation: to resolve or not?

CN Serhan - The American journal of pathology, 2010 - Elsevier
Because inflammation is appreciated as a unifying basis of many widely occurring diseases,
the mechanisms involved in its natural resolution are of considerable interest. Using …

Identification and quantification of bacterial genomes carrying antibiotic resistance genes and virulence factor genes for aquatic microbiological risk assessment

J Liang, G Mao, X Yin, L Ma, L Liu, Y Bai, T Zhang, J Qu - Water Research, 2020 - Elsevier
Aquatic ecosystems have been increasingly threatened by anthropogenic activities, eg,
wastewater discharge and farm operation. Several methods are adopted to evaluate the …

Expanding role of type II secretion in bacterial pathogenesis and beyond

NP Cianciotto, RC White - Infection and immunity, 2017 - Am Soc Microbiol
ABSTRACT Type II secretion (T2S) is one means by which Gram-negative pathogens
secrete proteins into the extracellular milieu and/or host organisms. Based upon recent …