Besides the broad development of nanotechnological approaches for cancer diagnosis and
therapy, currently, there is no significant progress in the treatment of different types of brain …

Blood-brain barrier (BBB) remains a significant obstacle to drug therapy for brain diseases.
Focused ultrasound (FUS) combined with microbubbles (MBs) can locally and transiently …

Background There is an emerging need for noninvasive neuromodulation techniques to
improve patient outcomes while minimizing adverse events and morbidity. Low-intensity …

Treating the brain with focused ultrasound (FUS) at low intensities elicits diverse responses
in neurons, astroglia, and the extracellular matrix. In combination with intravenously injected …

The opening of the blood–brain barrier (BBB) by focused ultrasound (FUS) coupled with
intravenously injected microbubbles can be leveraged as a form of immunotherapy for the …

The physiology of the vasculature in the central nervous system (CNS), which includes the
blood–brain barrier (BBB) and other factors, complicates the delivery of most drugs to the …

Ultrasound modulates the electrical activity of excitable cells and offers advantages over
other neuromodulatory techniques; for example, it can be noninvasively transmitted through …

Over the last decade, there has been a significant progress towards the development of
microbubbles as theranostics for a wide variety of biomedical applications. The unique …

Purpose: Paclitaxel shows little benefit in the treatment of glioma due to poor penetration
across the blood–brain barrier (BBB). Low-intensity pulsed ultrasound (LIPU) with …

Like cardiovascular disease and cancer, neurological disorders present an increasing
challenge for an ageing population. Whereas nonpharmacological procedures are routine …