The Wnt pathway: from signaling mechanisms to synthetic modulators
The Wnt pathway is central to a host of developmental and disease-related processes. The
remarkable conservation of this intercellular signaling cascade throughout metazoan …
remarkable conservation of this intercellular signaling cascade throughout metazoan …
Types of nuclear localization signals and mechanisms of protein import into the nucleus
Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment
that mediates the transport of proteins from the cytoplasm into the nucleus. This NLS …
that mediates the transport of proteins from the cytoplasm into the nucleus. This NLS …
Mitogen signaling strength and duration can control cell cycle decisions
Decades ago, mitogen-promoted signaling duration and strength were observed to be
sensed by the cell and to be critical for its decisions: to proliferate or differentiate. Landmark …
sensed by the cell and to be critical for its decisions: to proliferate or differentiate. Landmark …
Advances in targeting the WNT/β-catenin signaling pathway in cancer
WNT/β-catenin signaling orchestrates various physiological processes, including embryonic
development, growth, tissue homeostasis, and regeneration. Abnormal WNT/β-catenin …
development, growth, tissue homeostasis, and regeneration. Abnormal WNT/β-catenin …
Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling
Y Gu, Y Wang, L He, J Zhang, X Zhu, N Liu, J Wang… - Molecular cancer, 2021 - Springer
Background Hepatocellular carcinoma (HCC) is one of the most intractable tumors in the
world due to its high rate of recurrence and heterogeneity. Liver cancer initiating cells also …
world due to its high rate of recurrence and heterogeneity. Liver cancer initiating cells also …
Inhibition of Drp1 SUMOylation by ALR protects the liver from ischemia-reperfusion injury
J Huang, P **e, Y Dong, W An - Cell Death & Differentiation, 2021 - nature.com
Hepatic ischemic reperfusion injury (IRI) is a common complication of liver surgery. Although
an imbalance between mitochondrial fission and fusion has been identified as the cause of …
an imbalance between mitochondrial fission and fusion has been identified as the cause of …
Wnt/β-catenin signaling in colorectal cancer: Is therapeutic targeting even possible?
C Disoma, Y Zhou, S Li, J Peng, Z **a - Biochimie, 2022 - Elsevier
The Wnt/β-catenin signaling pathway has been implicated as the central mechanism that
drives colorectal carcinogenesis. Its activation is historically due to mutation on APC …
drives colorectal carcinogenesis. Its activation is historically due to mutation on APC …
Evolution of molecular targeted cancer therapy: mechanisms of drug resistance and novel opportunities identified by CRISPR-Cas9 screening
J Hou, Z He, T Liu, D Chen, B Wang, Q Wen… - Frontiers in …, 2022 - frontiersin.org
Molecular targeted therapy has revolutionized the landscape of cancer treatment due to
better therapeutic responses and less systemic toxicity. However, therapeutic resistance is a …
better therapeutic responses and less systemic toxicity. However, therapeutic resistance is a …
CRISPR/Cas9 as precision and high-throughput genetic engineering tools in gastrointestinal cancer research and therapy
Gastrointestinal cancer (GI) is one of the most serious and health-threatening diseases
worldwide. Many countries have encountered an escalating prevalence of shock. Therefore …
worldwide. Many countries have encountered an escalating prevalence of shock. Therefore …
Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors
By establishing multi-omics pipelines, we uncover overexpression and gene copy-number
alterations of nucleoporin-93 (NUP93), a nuclear pore component, in aggressive human …
alterations of nucleoporin-93 (NUP93), a nuclear pore component, in aggressive human …