Mechanistic landscape of membrane-permeabilizing peptides
Membrane permeabilizing peptides (MPPs) are as ubiquitous as the lipid bilayer
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …
Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles
M Yanez Arteta, T Kjellman… - Proceedings of the …, 2018 - National Acad Sciences
The development of safe and efficacious gene vectors has limited greatly the potential for
therapeutic treatments based on messenger RNA (mRNA). Lipid nanoparticles (LNPs) …
therapeutic treatments based on messenger RNA (mRNA). Lipid nanoparticles (LNPs) …
Physical principles of membrane shape regulation by the glycocalyx
Cells bend their plasma membranes into highly curved forms to interact with the local
environment, but how shape generation is regulated is not fully resolved. Here, we report a …
environment, but how shape generation is regulated is not fully resolved. Here, we report a …
PEGylated PRINT nanoparticles: the impact of PEG density on protein binding, macrophage association, biodistribution, and pharmacokinetics
JL Perry, KG Reuter, MP Kai, KP Herlihy, SW Jones… - Nano …, 2012 - ACS Publications
In this account, we varied PEGylation density on the surface of hydrogel PRINT
nanoparticles and systematically observed the effects on protein adsorption, macrophage …
nanoparticles and systematically observed the effects on protein adsorption, macrophage …
Cationic liposomes as vectors for nucleic acid and hydrophobic drug therapeutics
Cationic liposomes (CLs) are effective carriers of a variety of therapeutics. Their applications
as vectors of nucleic acids (NAs), from long DNA and mRNA to short interfering RNA …
as vectors of nucleic acids (NAs), from long DNA and mRNA to short interfering RNA …
Targeting nanoparticles to cancer
M Wang, M Thanou - Pharmacological research, 2010 - Elsevier
Nanotechnology applications in medicine, termed as nanomedicine, have introduced a
number of nanoparticles of variable chemistry and architecture for cancer imaging and …
number of nanoparticles of variable chemistry and architecture for cancer imaging and …
Ultrasound-triggered drug delivery for cancer treatment using drug delivery systems: From theoretical considerations to practical applications
Ultrasound-triggered drug delivery is now becoming a mature technology with first patients
enrolling in clinical trials. Having a clear overview of the field is complicated as it mixes …
enrolling in clinical trials. Having a clear overview of the field is complicated as it mixes …
[LIBRO][B] Surface and interfacial forces
A general introduction to surface and interfacial forces, perfectly combining theoretical
concepts, experimental techniques and practical applications. In this completely updated …
concepts, experimental techniques and practical applications. In this completely updated …
Ionizable lipid nanoparticles encapsulating barcoded mRNA for accelerated in vivo delivery screening
Messenger RNA (mRNA) has recently emerged as a promising class of nucleic acid therapy,
with the potential to induce protein production to treat and prevent a range of diseases …
with the potential to induce protein production to treat and prevent a range of diseases …
Influence of polyethylene glycol lipid desorption rates on pharmacokinetics and pharmacodynamics of siRNA lipid nanoparticles
BL Mui, YK Tam, M Jayaraman, SM Ansell, X Du… - … Therapy-Nucleic Acids, 2013 - cell.com
Lipid nanoparticles (LNPs) encapsulating short interfering RNAs that target hepatic genes
are advancing through clinical trials, and early results indicate the excellent gene silencing …
are advancing through clinical trials, and early results indicate the excellent gene silencing …