Mechanistic landscape of membrane-permeabilizing peptides

S Guha, J Ghimire, E Wu, WC Wimley - Chemical reviews, 2019 - ACS Publications
Membrane permeabilizing peptides (MPPs) are as ubiquitous as the lipid bilayer
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …

Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles

M Yanez Arteta, T Kjellman… - Proceedings of the …, 2018 - National Acad Sciences
The development of safe and efficacious gene vectors has limited greatly the potential for
therapeutic treatments based on messenger RNA (mRNA). Lipid nanoparticles (LNPs) …

Physical principles of membrane shape regulation by the glycocalyx

CR Shurer, JCH Kuo, LDM Roberts, JG Gandhi… - Cell, 2019 - cell.com
Cells bend their plasma membranes into highly curved forms to interact with the local
environment, but how shape generation is regulated is not fully resolved. Here, we report a …

PEGylated PRINT nanoparticles: the impact of PEG density on protein binding, macrophage association, biodistribution, and pharmacokinetics

JL Perry, KG Reuter, MP Kai, KP Herlihy, SW Jones… - Nano …, 2012 - ACS Publications
In this account, we varied PEGylation density on the surface of hydrogel PRINT
nanoparticles and systematically observed the effects on protein adsorption, macrophage …

Cationic liposomes as vectors for nucleic acid and hydrophobic drug therapeutics

KK Ewert, P Scodeller, L Simón-Gracia, VM Steffes… - Pharmaceutics, 2021 - mdpi.com
Cationic liposomes (CLs) are effective carriers of a variety of therapeutics. Their applications
as vectors of nucleic acids (NAs), from long DNA and mRNA to short interfering RNA …

Targeting nanoparticles to cancer

M Wang, M Thanou - Pharmacological research, 2010 - Elsevier
Nanotechnology applications in medicine, termed as nanomedicine, have introduced a
number of nanoparticles of variable chemistry and architecture for cancer imaging and …

Ultrasound-triggered drug delivery for cancer treatment using drug delivery systems: From theoretical considerations to practical applications

T Boissenot, A Bordat, E Fattal, N Tsapis - Journal of Controlled Release, 2016 - Elsevier
Ultrasound-triggered drug delivery is now becoming a mature technology with first patients
enrolling in clinical trials. Having a clear overview of the field is complicated as it mixes …

[LIBRO][B] Surface and interfacial forces

HJ Butt, M Kappl - 2018 - books.google.com
A general introduction to surface and interfacial forces, perfectly combining theoretical
concepts, experimental techniques and practical applications. In this completely updated …

Ionizable lipid nanoparticles encapsulating barcoded mRNA for accelerated in vivo delivery screening

PPG Guimaraes, R Zhang, R Spektor, M Tan… - Journal of Controlled …, 2019 - Elsevier
Messenger RNA (mRNA) has recently emerged as a promising class of nucleic acid therapy,
with the potential to induce protein production to treat and prevent a range of diseases …

Influence of polyethylene glycol lipid desorption rates on pharmacokinetics and pharmacodynamics of siRNA lipid nanoparticles

BL Mui, YK Tam, M Jayaraman, SM Ansell, X Du… - … Therapy-Nucleic Acids, 2013 - cell.com
Lipid nanoparticles (LNPs) encapsulating short interfering RNAs that target hepatic genes
are advancing through clinical trials, and early results indicate the excellent gene silencing …