Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …

Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) have served as
prototypes for growth factor and receptor tyrosine kinase function for more than 25 years …

Platelet-derived growth factor (PDGF) is a major mitogen for connective tissue cells and
certain other cell types. It is a dimeric molecule consisting of disulfide-bonded, structurally …

Chronic and acute renal diseases, irrespective of the initiating cause, have inflammation and
immune system activation as a common underlying mechanism. The purpose of this review …

Platelet-derived growth factor (PDGF) isoforms play a major role in stimulating the
replication, survival, and migration of myofibroblasts during the pathogenesis of fibrotic …

Aptamers are single-stranded nucleic acid molecules that possess properties comparable to
those of protein monoclonal antibodies, and thus are clear alternatives to long established …

Patients with end-stage renal disease suffer from complex hemostatic disorders. Uremic
patients show a bleeding diathesis that is mainly due to abnormalities of primary …

Platelet-derived growth factor (PDGF) exerts its stimulatory effects on cell growth and motility
by binding to two related protein tyrosine kinase receptors. Ligand binding induces receptor …

Platelet‐derived growth factor (PDGF) isoforms and their receptors have important roles
during embryogenesis, particularly in the development of various mesenchymal cell types in …

Expression of connective tissue growth factor in human renal fibrosis. Chronic renal failure
may occur in etiologically diverse renal diseases and can be caused by hemodynamic …