Circulating cell-free DNA enables noninvasive diagnosis of heart transplant rejection

I De Vlaminck, HA Valantine, TM Snyder… - Science translational …, 2014 - science.org
Monitoring allograft health is an important component of posttransplant therapy.
Endomyocardial biopsy is the current gold standard for cardiac allograft monitoring but is an …

Temporal response of the human virome to immunosuppression and antiviral therapy

I De Vlaminck, KK Khush, C Strehl, B Kohli, H Luikart… - Cell, 2013 - cell.com
There are few substantive methods to measure the health of the immune system, and the
connection between immune strength and the viral component of the microbiome is poorly …

Liquid biopsies to monitor solid organ transplant function: a review of new biomarkers

JGHP Verhoeven, K Boer… - Therapeutic drug …, 2018 - journals.lww.com
Despite modern immunosuppressive therapy, allograft rejection remains a major cause of
solid organ transplant dysfunction. For clinical care, organ transplant function is routinely …

Cardiovascular magnetic resonance for rejection surveillance after cardiac transplantation

C Anthony, M Imran, J Pouliopoulos, S Emmanuel… - Circulation, 2022 - Am Heart Assoc
Background: Endomyocardial biopsy (EMB) is the gold standard method for surveillance of
acute cardiac allograft rejection (ACAR) despite its invasive nature. Cardiovascular …

Advances in diagnostics for transplant rejection

M Nasr, T Sigdel, M Sarwal - Expert review of molecular …, 2016 - Taylor & Francis
Introduction: Identification of allograft injury, including acute clinical and subclinical injury, is
vital in increasing the longevity of the transplanted organ. Acute rejection, which occurs as a …

[HTML][HTML] Cardiovascular magnetic resonance in heart transplant patients: diagnostic value of quantitative tissue markers: T2 map** and extracellular volume fraction …

E Vermes, CΩ PantalΩon, A Auvet… - Journal of …, 2018 - Elsevier
Background The diagnosis of acute rejection in cardiac transplant recipients requires
invasive technique with endomyocardial biopsy (EMB) which has risks and limitations …

Serum exosomal protein profiling for the non-invasive detection of cardiac allograft rejection

PJ Kennel, A Saha, DA Maldonado, R Givens… - The Journal of Heart and …, 2018 - Elsevier
Background Exosomes are cell-derived circulating vesicles that play an important role in cell–
cell communication. Exosomes are actively assembled and carry messenger RNAs …

Randomized pilot trial of gene expression profiling versus heart biopsy in the first year after heart transplant: early invasive monitoring attenuation through gene …

J Kobashigawa, J Patel, B Azarbal… - Circulation: Heart …, 2015 - Am Heart Assoc
Background—The endomyocardial biopsy (EMB) is considered the gold standard in
rejection surveillance post cardiac transplant, but is invasive, with risk of complications. A …

Safety of right and left ventricular endomyocardial biopsy in heart transplantation and cardiomyopathy patients

K Bermpeis, G Esposito, E Gallinoro, P Paolisso… - Heart Failure, 2022 - jacc.org
Background Endomyocardial biopsy (EMB) facilitates a histopathologic diagnosis with
unique prognostic and therapeutic implications in both native and donor hearts. It is a …

Point-of-care non-invasive enzyme-cleavable nanosensors for acute transplant rejection detection

SJ Liu, K Ma, LS Liu, K Wang, YA Zhang, ZR Bi… - Biosensors and …, 2022 - Elsevier
Accurate and non-invasive monitoring of allograft posttransplant is essential for early
detection of acute cellular rejection and determines the long-term survival of the graft …