This review is focused on purinergic neurotransmission, ie, ATP released from nerves as a
transmitter or cotransmitter to act as an extracellular signaling molecule on both pre-and …

In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

Intrinsic primary afferent neurons (IPANs) of the enteric nervous system are quite different
from all other peripheral neurons. The IPANs are transducers of physiological stimuli …

Significant progress in understanding the pharmacological characteristics and physiological
importance of homomeric and heteromeric P2X channels has been achieved in recent …

Purinergic signalling plays major roles in the physiology and pathophysiology of digestive
organs. Adenosine 5′-triphosphate (ATP), together with nitric oxide and vasoactive …

The physiological properties, shapes, projections and neurochemistries of Dogiel type II
neurons have been thoroughly investigated in the guinea-pig intestine in which these …

Vagal mechanoreceptors to the guinea‐pig oesophagus, recorded extracellularly, in vitro,
fired spontaneously at 3.3±0.2 Hz,(n= 75, from 57 animals), and had low thresholds to …

In this review, evidence is presented to support the hypothesis that mechanosensory
transduction occurs in tubes and sacs and can initiate visceral pain. Experimental evidence …

Bile acids (BAs) are known to be important regulators of intestinal motility and epithelial fluid
and electrolyte transport. Over the past two decades, significant advances in identifying and …

Cellular signaling via extracellular nucleotides appears to play a major role in the
functioning of the peripheral nervous system. Information regarding the functional …