ABC transporters are essential for cellular physiology. Humans have 48 ABC genes
organized into seven distinct families. Of these genes, 44 (in five distinct families) encode for …

Lipids are a class of complex hydrophobic molecules derived from fatty acids that not only
form the structural basis of biological membranes but also regulate metabolism and maintain …

Human ABC transporter ABCD1 transports very long-chain fatty acids from cytosol to
peroxisome for β-oxidation, dysfunction of which usually causes the X-linked …

ATP‐binding cassette (ABC) superfamily is one of the largest groups of primary active
transporters that could be found in all kingdoms of life from bacteria to humans. In humans …

ABCB1 is a broad-spectrum efflux pump central to cellular drug handling and multidrug
resistance in humans. However, how it is able to recognize and transport a wide range of …

Human ABC transporters ABCD1–3 are all localized on the peroxisomal membrane and
participate in the β-oxidation of fatty acyl-CoAs, but they differ from each other in substrate …

Dysfunctions of ATP-binding cassette, subfamily D, member 1 (ABCD1) cause X-linked
adrenoleukodystrophy, a rare neurodegenerative disease that affects all human tissues …

Adrenoleukodystrophy protein (ALDP) is responsible for the transport of very-long-chain fatty
acids (VLCFAs) and corresponding CoA-esters across the peroxisomal membrane …

Carnitine O-acetyltransferase (CRAT) is a key mitochondrial enzyme involved in maintaining
metabolic homeostasis by mediating the reversible transfer of acetyl groups between acetyl …

ATP-binding cassette (ABC) transporters are proteins responsible for active transport of
various compounds, from small ions to macromolecules, across membranes. Proteins from …