CD8+ T cell differentiation and dysfunction in cancer
M Philip, A Schietinger - Nature Reviews Immunology, 2022 - nature.com
CD8+ T cells specific for cancer cells are detected within tumours. However, despite their
presence, tumours progress. The clinical success of immune checkpoint blockade and …
presence, tumours progress. The clinical success of immune checkpoint blockade and …
Tumour microenvironment of pancreatic cancer: immune landscape is dictated by molecular and histopathological features
E Karamitopoulou - British journal of cancer, 2019 - nature.com
Pancreatic cancer is a lethal disease, with fewer than 7% of patients surviving beyond 5
years following diagnosis. Immune responses are known to influence tumour progression …
years following diagnosis. Immune responses are known to influence tumour progression …
Human tumor-associated macrophage and monocyte transcriptional landscapes reveal cancer-specific reprogramming, biomarkers, and therapeutic targets
The roles of tumor-associated macrophages (TAMs) and circulating monocytes in human
cancer are poorly understood. Here, we show that monocyte subpopulation distribution and …
cancer are poorly understood. Here, we show that monocyte subpopulation distribution and …
Inflamed and non-inflamed classes of HCC: a revised immunogenomic classification
C Montironi, F Castet, PK Haber, R Pinyol… - Gut, 2023 - gut.bmj.com
Objective We previously reported a characterisation of the hepatocellular carcinoma (HCC)
immune contexture and described an immune-specific class. We now aim to further …
immune contexture and described an immune-specific class. We now aim to further …
Five latent factors underlie response to immunotherapy
J Usset, A Rosendahl Huber, MA Andrianova… - Nature Genetics, 2024 - nature.com
Only a subset of patients treated with immune checkpoint inhibitors (CPIs) respond to the
treatment, and distinguishing responders from non-responders is a major challenge. Many …
treatment, and distinguishing responders from non-responders is a major challenge. Many …
An inflammatory response-related gene signature can impact the immune status and predict the prognosis of hepatocellular carcinoma
Z Lin, Q Xu, D Miao, F Yu - Frontiers in oncology, 2021 - frontiersin.org
Background Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, which
makes the prognostic prediction challenging. As part of the active cross-talk between the …
makes the prognostic prediction challenging. As part of the active cross-talk between the …
Landscape of cancer-associated fibroblasts identifies the secreted biglycan as a protumor and immunosuppressive factor in triple-negative breast cancer
Cancer-associated fibroblasts (CAFs) are essential for tumor microenvironment remodeling
and correlate with tumor progression. However, interactions between CAFs and tumor cells …
and correlate with tumor progression. However, interactions between CAFs and tumor cells …
The immune subtypes and landscape of squamous cell carcinoma
Purpose: To identify immune subtypes and investigate the immune landscape of squamous
cell carcinomas (SCC), which share common etiology and histologic features. Experimental …
cell carcinomas (SCC), which share common etiology and histologic features. Experimental …
Cancer cell plasticity defines response to immunotherapy in cutaneous squamous cell carcinoma
Immune checkpoint blockade (ICB) approaches have changed the therapeutic landscape for
many tumor types. However, half of cutaneous squamous cell carcinoma (cSCC) patients …
many tumor types. However, half of cutaneous squamous cell carcinoma (cSCC) patients …
Somatic 9p24.1 alterations in HPV– head and neck squamous cancer dictate immune microenvironment and anti-PD-1 checkpoint inhibitor activity
Somatic copy number alterations (SCNAs), generally losses containing interferons and
interferon-pathway genes, many on chromosome 9p, predict immune-cold, immune …
interferon-pathway genes, many on chromosome 9p, predict immune-cold, immune …