Extracellular vesicles (EVs) are particles naturally released from cells that are delimited by a
lipid bilayer and are unable to replicate. How the EVs cross the Blood–Brain barrier (BBB) in …

For a blood-borne cancer therapeutic agent to be effective, it must cross the blood vessel
wall to reach cancer cells in adequate quantities, and it must overcome the resistance …

Mammalian models including non‐human primates, pigs and rodents have been used
extensively to study the mechanisms of cardiovascular disease. However, there is an …

The blood–brain barrier (BBB) restricts free access of molecules between the blood and the
brain and is essential for regulating the neural microenvironment. Here, we describe how …

The neuroscience community has witnessed a tremendous expansion of glia research. Glial
cells are now on center stage with leading roles in the development, maturation, and …

Endothelial cells play a major part in the regulation of vascular permeability and
angiogenesis. According to their duty to fit the needs of the underlying tissue, endothelial …

The zebrafish is ideal for studying embryogenesis and is increasingly applied to model
human disease. In these contexts, RNA-sequencing (RNA-seq) provides mechanistic …

The human central nervous system (CNS) vasculature expresses a distinctive barrier
phenotype, the blood–brain barrier (BBB). As the BBB contributes to low efficiency in CNS …

Endothelial cells (ECs) in the central nervous system (CNS) acquire their specialized blood–
brain barrier (BBB) properties in response to extrinsic signals, with Wnt/β-catenin signaling …

The blood-brain barrier (BBB) is a unique set of properties of the brain vasculature which
severely restrict its permeability to proteins and small molecules. Classic chick-quail chimera …