Collective cell migration on extracellular matrix (ECM) networks is a key biological process
involved in development, tissue homeostasis and diseases such as metastatic cancer …

The process of drug discovery and pre‐clinical testing is currently inefficient, expensive, and
time‐consuming. Most importantly, the success rate is unsatisfactory, as only a small …

Cells cultured on stiff 2D substrates exert high intracellular force, resulting in mechanical
deformation of their nuclei. This nuclear deformation (ND) plays a crucial role in the transport …

Neurons in the brain communicate with each other at their synapses. It has long been
understood that this communication occurs through biochemical processes. Here, we reveal …

Cells are very sensitive to the shear stress (SS). However, undesirable SS is generated
during physiological process such as collective cell migration (CCM) and influences the …

Cell–matrix interactions, mediated by cellular force and matrix remodeling, result in dynamic
reciprocity that drives numerous biological processes and disease progression. Currently …

Movement of cell clusters along extracellular matrices (ECM) during tissue development,
wound healing, and early stage of cancer invasion involve various inter-connected migration …

Colorectal cancer metastasis is governed by a variety of chemical and mechanical signaling
that are largely influenced by cancer-associated fibroblasts (CAFs) in the tumor …

This study introduces a comprehensive methodology for designing, fabricating, and testing a
MEMS stage integrated into a commercial testing device, with a focus on enabling …

Human fibrotic diseases constitute a major health problem worldwide. Fibrosis involves
significant etiological heterogeneity and encompasses a wide spectrum of diseases …