Neurons are highly susceptible to DNA damage accumulation due to their large energy
requirements, elevated transcriptional activity, and long lifespan. While newer research has …

Automated gait assessment tests are used in studies of disorders characterized by gait
impairment. CatWalk XT is one of the first commercially available automated systems for …

Capacitance of biological membranes is determined by the properties of the lipid portion of
the membrane as well as the morphological features of a cell. In neurons, membrane …

Loss of the ATM protein kinase in humans results in Ataxia-telangiectasia, a disorder
characterized by childhood-onset neurodegeneration of the cerebellum as well as cancer …

Ageing is the greatest risk factor of late‐onset neurodegenerative diseases. In the realm of
sporadic tauopathies, modelling the process of biological ageing in experimental animals …

Mutations in ion channel genes underlie a number of human neurological diseases.
Historically, human mutations in ion channel genes, the so-called channelopathies, have …

Computational neural network modelling is an emerging approach for optimization of drug
treatment of neurological disorders and fine-tuning of rehabilitation strategies. In the current …

Nonsense mutations are a type of mutations which results in a premature termination codon
occurrence. In general, these mutations have been considered to be among the most …

Cerebellar neurodegeneration is a classical feature of ataxia telangiectasia (AT), an
autosomal recessive condition caused by loss-of-function mutation of the ATM gene, a gene …

ATM depletion is associated with the multisystemic neurodegenerative syndrome ataxia–
telangiectasia (A–T). The exact linkage between neurodegeneration and ATM deficiency …