Glutathione homeostasis and functions: potential targets for medical interventions

VI Lushchak - Journal of amino acids, 2012 - Wiley Online Library
Glutathione (GSH) is a tripeptide, which has many biological roles including protection
against reactive oxygen and nitrogen species. The primary goal of this paper is to …

[หนังสือ][B] Oxidation and antioxidants in organic chemistry and biology

ET Denisov, IB Afanas' ev - 2005 - taylorfrancis.com
Providing a comprehensive review of reactions of oxidation for different classes of organic
compounds and polymers, and biological processes mediated by free radicals, Oxidation …

SMURF2 predisposes cancer cell toward ferroptosis in GPX4-independent manners by promoting GSTP1 degradation

W Zhang, J Dai, G Hou, H Liu, S Zheng, X Wang, Q Lin… - Molecular cell, 2023 - cell.com
Ferroptosis is a non-apoptotic form of regulated cell death. Glutathione (GSH) peroxidase 4
(GPX4) and GSH-independent ferroptosis suppressor protein 1 (FSP1) have been identified …

Polystyrene microplastics (PS-MPs) toxicity induced oxidative stress and intestinal injury in nematode Caenorhabditis elegans

Y Yu, H Chen, X Hua, Y Dang, Y Han, Z Yu… - Science of the Total …, 2020 - Elsevier
To understand the toxicity and mechanism of polystyrene microplastics (PS-MPs) exposure,
Caenorhabditis elegans (C. elegans) was exposed to various concentrations (0, 0.1, 1, 10 …

Generation and biological activities of oxidized phospholipids

VN Bochkov, OV Oskolkova, KG Birukov… - Antioxidants & redox …, 2010 - liebertpub.com
Glycerophospholipids represent a common class of lipids critically important for integrity of
cellular membranes. Oxidation of esterified unsaturated fatty acids dramatically changes …

Acetaminophen-induced liver injury: Molecular mechanism and treatments from natural products

J Liao, Q Lu, Z Li, J Li, Q Zhao, J Li - Frontiers in pharmacology, 2023 - frontiersin.org
Acetaminophen (APAP) is a widely used analgesic and antipyretic over-the-counter
medicine worldwide. Hepatotoxicity caused by APAP overdose is one of the leading causes …

Antioxidant role of glutathione S-transferases: 4-Hydroxynonenal, a key molecule in stress-mediated signaling

SS Singhal, SP Singh, P Singhal, D Horne… - Toxicology and applied …, 2015 - Elsevier
Hydroxy-2-trans-nonenal (4HNE), one of the major end products of lipid peroxidation (LPO),
has been shown to induce apoptosis in a variety of cell lines. It appears to modulate …

DNA damage and oxidative stress induced by imidacloprid exposure in different tissues of the Neotropical fish Prochilodus lineatus

CED Vieira, MR Pérez, RDA Acayaba, CCM Raimundo… - Chemosphere, 2018 - Elsevier
Imidacloprid (IMI), a systemic neonicotinoid insecticide widely used in worldwide scale, is
reported in freshwater bodies. Nevertheless, there is a lack of information about IMI …

[HTML][HTML] Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: protection against reactive oxygen and nitrogen species …

H Zhu, K Itoh, M Yamamoto, JL Zweier, Y Li - FEBS letters, 2005 - Elsevier
Understanding the molecular pathway (s) of antioxidant gene regulation is of crucial
importance for develo** antioxidant-inducing agents for the intervention of oxidative …

Resveratrol protects primary rat hepatocytes against oxidative stress damage:: Activation of the Nrf2 transcription factor and augmented activities of antioxidant …

JA Rubiolo, G Mithieux, FV Vega - European journal of pharmacology, 2008 - Elsevier
Oxidative stress is recognized as an important factor in the development of liver pathologies.
The reactive oxygen species endogenously generated or as a consequence of xenobiotic …