Trichloroethylene: An Update on an Environmental Contaminant with Multiple Health Effects
LH Lash - Annual Review of Pharmacology and Toxicology, 2024 - annualreviews.org
The halogenated solvent trichloroethylene (TCE) has had many uses in medicine,
construction, consumer products, and the military. Many of these uses have been …
construction, consumer products, and the military. Many of these uses have been …
Low-dose inhalation exposure to trichloroethylene induces dopaminergic neurodegeneration in rodents
Trichloroethylene (TCE) is one of the most pervasive environmental contaminants in the
world and is associated with Parkinson disease (PD) risk. Experimental models in rodents …
world and is associated with Parkinson disease (PD) risk. Experimental models in rodents …
Renal Glutathione: Dual roles as antioxidant protector and bioactivation promoter
LH Lash - Biochemical Pharmacology, 2024 - Elsevier
The tripeptide glutathione (GSH) possesses two key structural features, namely the
nucleophilic sulfur and the γ-glutamyl isopeptide bond. The former allows GSH to serve as a …
nucleophilic sulfur and the γ-glutamyl isopeptide bond. The former allows GSH to serve as a …
Reducing uncertainty in dose–response assessments by incorporating Bayesian benchmark dose modeling and in vitro data on population variability
There are two primary sources of uncertainty in the interpretability of toxicity values, like the
reference dose (RfD): estimates of the point of departure (POD) and the absence of chemical …
reference dose (RfD): estimates of the point of departure (POD) and the absence of chemical …
Unveiling the mechanisms of trichloroethylene hypersensitivity syndrome: Exploring the role of connexin 43 gap junctions in severe skin damage
B Jiao, H Jiang, S Liu, Y Wang, Y Chen, H Duan… - Food and Chemical …, 2024 - Elsevier
Trichloroethylene (TCE), extensively used as an organic solvent in various industrial
applications, has been identified as a causative factor in inducing hypersensitivity syndrome …
applications, has been identified as a causative factor in inducing hypersensitivity syndrome …
Incorporating new approach methods (NAMs) data in dose–response assessments: The future is now!
Regulatory dose–response assessments traditionally rely on in vivo data and default
assumptions. New Approach Methods (NAMs) present considerable opportunities to both …
assumptions. New Approach Methods (NAMs) present considerable opportunities to both …
[HTML][HTML] The role of PANoptosis in renal vascular endothelial cells: Implications for trichloroethylene-induced kidney injury
H **e, B Liang, Q Zhu, L Wang, H Li, Z Qin… - Ecotoxicology and …, 2024 - Elsevier
Trichloroethylene (TCE), a widely distributed environmental chemical contaminant, is
extensively dispersed throughout the environment. Individuals who are exposed to TCE may …
extensively dispersed throughout the environment. Individuals who are exposed to TCE may …
Evaluating scientific confidence in the concordance of in vitro and in vivo protective points of departure
To fulfil the promise of reducing reliance on mammalian in vivo laboratory animal studies,
new approach methods (NAMs) need to provide a confident basis for regulatory decision …
new approach methods (NAMs) need to provide a confident basis for regulatory decision …
Wnt5a promotes Kupffer cell activation in trichloroethylene-induced immune liver injury
L Gao, YN Ding, PC Zhou, LL Dong… - Toxicology and …, 2025 - journals.sagepub.com
Trichloroethylene (TCE) is a volatile, colorless liquid that is widely used as a chlorinated
organic vehicle in industrial production and processing industries. Many workers exposed to …
organic vehicle in industrial production and processing industries. Many workers exposed to …
Invited Perspective: Improved Risk Characterization for Trichloroethylene and Perchloroethylene Based on New Analyses of Glutathione Conjugation Rates
LH Lash - Environmental Health Perspectives, 2022 - ehp.niehs.nih.gov
Information System (IRIS). EPA/635/R-08/011A. Washington, DC: US EPA. 4. NTP (National
Toxicology Program). 1988. Toxicology and carcinogenesis studies of trichloroethylene …
Toxicology Program). 1988. Toxicology and carcinogenesis studies of trichloroethylene …