Intervertebral disc degeneration (IVDD) has been the major contributor to chronic lower back
pain (LBP). Abnormal apoptosis, senescence, and pyroptosis of IVD cells, extracellular …

Although previous RNA sequencing methods have been widely used in orthopedic research
and have provided ideas for therapeutic strategies, the specific mechanisms of some …

Intervertebral disc degeneration (IDD) has been considered as the primary pathological
mechanism that underlies low back pain. Understanding the molecular mechanisms …

Stem cell transplantation has been proved a promising therapeutic instrument in
intervertebral disc degeneration (IVDD). However, the elevation of oxidative stress in the …

Intervertebral disc degeneration (IDD) is a major cause of discogenic pain, and is attributed
to the dysfunction of nucleus pulposus, annulus fibrosus, and cartilaginous endplate (CEP) …

Background Nucleus pulposus cell (NPC) death and progressive reduction play important
roles in intervertebral disc degeneration (IVDD). As part of a damage-associated molecular …

The intervertebral disc (IVD) acts as a fibrocartilaginous joint to anchor adjacent vertebrae.
Although several studies have demonstrated the cellular heterogeneity of adult mature IVDs …

Intervertebral disc degeneration (IVDD) leads to a series of degenerative spine diseases.
Clinical treatment of IVDD is mainly surgery, lacking effective drugs to alleviate intervertebral …

Degenerative disc disease (DDD), a major contributor to discogenic pain, which is mainly
resulted from the dysfunction of nucleus pulposus (NP), annulus fibrosis (AF) and cartilage …

The complexity of the human intervertebral disc (IVD) has hindered the elucidation of the
microenvironment and mechanisms underlying IVD degeneration (IVDD). Here we …