Cytokines: from clinical significance to quantification

C Liu, D Chu, K Kalantar‐Zadeh, J George… - Advanced …, 2021 - Wiley Online Library
Cytokines are critical mediators that oversee and regulate immune and inflammatory
responses via complex networks and serve as biomarkers for many diseases. Quantification …

Cytokine networks in the pathogenesis of rheumatoid arthritis

N Kondo, T Kuroda, D Kobayashi - International journal of molecular …, 2021 - mdpi.com
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic systemic
inflammation causing progressive joint damage that can lead to lifelong disability. The …

Signaling pathways in rheumatoid arthritis: implications for targeted therapy

Q Ding, W Hu, R Wang, Q Yang, M Zhu, M Li… - Signal transduction and …, 2023 - nature.com
Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …

Nanozyme-reinforced hydrogel as a H2O2-driven oxygenerator for enhancing prosthetic interface osseointegration in rheumatoid arthritis therapy

Y Zhao, S Song, D Wang, H Liu, J Zhang, Z Li… - Nature …, 2022 - nature.com
Stem cell-based therapy has drawn attention for enhancing the osseointegration efficiency
after joint replacement in the rheumatoid arthritis (RA). However, therapeutic efficacy of this …

Update on the pathomechanism, diagnosis, and treatment options for rheumatoid arthritis

YJ Lin, M Anzaghe, S Schülke - Cells, 2020 - mdpi.com
Rheumatoid arthritis (RA) is an autoimmune disease that involves multiple joints bilaterally.
It is characterized by an inflammation of the tendon (tenosynovitis) resulting in both cartilage …

The association between systemic immune-inflammation index and rheumatoid arthritis: evidence from NHANES 1999–2018

B Liu, J Wang, Y Li, K Li, Q Zhang - Arthritis research & therapy, 2023 - Springer
Purpose We aimed to explore the relationship between the systemic immune-inflammation
index (SII) and rheumatoid arthritis (RA) using NHANES from 1999 to 2018. Methods We …

Significance of interleukin (IL)-4 and IL-13 in inflammatory arthritis

M Iwaszko, S Biały, K Bogunia-Kubik - Cells, 2021 - mdpi.com
Interleukin (IL)-4 and IL-13 belong to the T helper 2 (Th2) cytokine family, along with IL-3, IL-
5, and IL-9. These cytokines are key mediators of allergic inflammation. They have important …

The IL-1 family of cytokines and receptors in rheumatic diseases

CA Dinarello - Nature Reviews Rheumatology, 2019 - nature.com
More than any other cytokine family, the 11 members of the IL-1 family are associated with
innate immune responses, which occur in acute inflammation and chronic inflammatory …

Function and role of regulatory T cells in rheumatoid arthritis

Q Jiang, G Yang, Q Liu, S Wang, D Cui - Frontiers in immunology, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is a systemic and heterogeneous autoimmune disease with
symmetrical polyarthritis as its critical clinical manifestation. The basic cause of autoimmune …

Recent advances on signaling pathways and their inhibitors in rheumatoid arthritis

S Liu, H Ma, H Zhang, C Deng, P **n - Clinical Immunology, 2021 - Elsevier
Rheumatoid arthritis (RA) is characterized by systemic synovitis leading to joint destruction
in which imbalances in pro-inflammatory and anti-inflammatory cytokines promote the …