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Organic cation transporters in health and disease
H Koepsell - Pharmacological reviews, 2020 - Elsevier
The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN) 1, OCTN2,
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …
Role of SLC transporters in toxicity induced by anticancer drugs
Introduction. Membrane transporters are integral to the maintenance of cellular integrity of all
tissue and cell types. While transporters play an established role in the systemic …
tissue and cell types. While transporters play an established role in the systemic …
Assessment of substrate-dependent ligand interactions at the organic cation transporter OCT2 using six model substrates
Organic cation transporter (OCT) 2 mediates the entry step for organic cation secretion by
renal proximal tubule cells and is a site of unwanted drug-drug interactions (DDIs). But …
renal proximal tubule cells and is a site of unwanted drug-drug interactions (DDIs). But …
Machine learning models identify new inhibitors for human OATP1B1
TR Lane, F Urbina, X Zhang, M Fye… - Molecular …, 2022 - ACS Publications
The uptake transporter OATP1B1 (SLC01B1) is largely localized to the sinusoidal
membrane of hepatocytes and is a known victim of unwanted drug–drug interactions …
membrane of hepatocytes and is a known victim of unwanted drug–drug interactions …
Importance of OCT2 and MATE1 for the Cimetidine–Metformin Interaction: insights from investigations of polarized transport in single-and double-transfected MDCK …
F Müller, D Weitz, K Mertsch, J König… - Molecular …, 2018 - ACS Publications
Cimetidine decreases the renal clearance of metformin by inhibition of renal tubular cation
transport, and the underlying molecular mechanisms are still not fully understood. We …
transport, and the underlying molecular mechanisms are still not fully understood. We …
[HTML][HTML] Novel drug transporter substrates identification: An innovative approach based on metabolomic profiling, in silico ligand screening and biological validation
Solute carrier (SLC) transport proteins are fundamental for the translocation of endogenous
compounds and drugs across membranes, thus playing a critical role in disease …
compounds and drugs across membranes, thus playing a critical role in disease …
Quantitative analysis of elevation of serum creatinine via renal transporter inhibition by trimethoprim in healthy subjects using physiologically-based pharmacokinetic …
T Nakada, T Kudo, T Kume, H Kusuhara, K Ito - Drug metabolism and …, 2018 - Elsevier
Serum creatinine (SCr) levels rise during trimethoprim therapy for infectious diseases. This
study aimed to investigate whether the elevation of SCr can be quantitatively explained …
study aimed to investigate whether the elevation of SCr can be quantitatively explained …
[HTML][HTML] In vitro inhibition of renal OCT2 and MATE1 secretion by antiemetic drugs
The organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1
(MATE1) mediate the renal secretion of drugs. Recent studies suggest that ondansetron, a 5 …
(MATE1) mediate the renal secretion of drugs. Recent studies suggest that ondansetron, a 5 …
[HTML][HTML] Transport turnover rates for human OCT2 and MATE1 expressed in Chinese hamster ovary cells
X Zhang, SH Wright - International journal of molecular sciences, 2022 - mdpi.com
MATE1 (multidrug and toxin extruder 1) and OCT2 (organic cation transporter 2) play critical
roles in organic cation excretion by the human kidney. The transporter turnover rate (TOR) is …
roles in organic cation excretion by the human kidney. The transporter turnover rate (TOR) is …
Multiple computational approaches for predicting drug interactions with human equilibrative nucleoside transporter 1
Equilibrativenucleoside transporters (ENTs) participate in the pharmacokinetics and
disposition of nucleoside analog drugs. Understanding drug interactions with the ENTs may …
disposition of nucleoside analog drugs. Understanding drug interactions with the ENTs may …