Variability of human pluripotent stem cell lines
Human pluripotent stem cells derived from embryos (human Embryonic Stem Cells or
hESCs) or generated by direct reprogramming of somatic cells (human Induced Pluripotent …
hESCs) or generated by direct reprogramming of somatic cells (human Induced Pluripotent …
Corneal cell therapy: with iPSCs, it is no more a far-sight
K Chakrabarty, R Shetty, A Ghosh - Stem cell research & therapy, 2018 - Springer
Human-induced pluripotent stem cells (hiPSCs) provide a personalized approach to study
conditions and diseases including those of the eye that lack appropriate animal models to …
conditions and diseases including those of the eye that lack appropriate animal models to …
[HTML][HTML] Uncompensated mitochondrial oxidative stress underlies heart failure in an iPSC-derived model of congenital heart disease
Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease with 30%
mortality from heart failure (HF) in the first year of life, but the cause of early HF remains …
mortality from heart failure (HF) in the first year of life, but the cause of early HF remains …
[HTML][HTML] Transcriptomes of Dravet syndrome iPSC derived GABAergic cells reveal dysregulated pathways for chromatin remodeling and neurodevelopment
Dravet syndrome (DS) is an early onset refractory epilepsy typically caused by de novo
heterozygous variants in SCN1A encoding the α-subunit of the neuronal sodium channel Na …
heterozygous variants in SCN1A encoding the α-subunit of the neuronal sodium channel Na …
New drug discovery paradigms for retinal diseases: a focus on retinal organoids
DM Aasen, MN Vergara - Journal of Ocular Pharmacology and …, 2020 - liebertpub.com
Retinal disease represents a growing global problem, both in terms of quality of life and
economic impact, yet new therapies are not being developed at a sufficient rate to meet this …
economic impact, yet new therapies are not being developed at a sufficient rate to meet this …
The progress in corneal translational medicine
Cornea tissue is in high demand by tissue donation centres globally, and thus tissue
engineering cornea, which is the main topic of corneal translational medicine, can serve as …
engineering cornea, which is the main topic of corneal translational medicine, can serve as …
Hypoxia enhances anti-fibrotic properties of extracellular vesicles derived from hiPSCs via the miR302b-3p/TGFβ/SMAD2 axis
Background Cardiac fibrosis is one of the top killers among fibrotic diseases and continues
to be a global unaddressed health problem. The lack of effective treatment combined with …
to be a global unaddressed health problem. The lack of effective treatment combined with …
Aromatic l-amino acid decarboxylase deficiency: a patient-derived neuronal model for precision therapies
Aromatic l-amino acid decarboxylase (AADC) deficiency is a complex inherited neurological
disorder of monoamine synthesis which results in dopamine and serotonin deficiency. The …
disorder of monoamine synthesis which results in dopamine and serotonin deficiency. The …
Addressing variability and heterogeneity of induced pluripotent stem cell-derived cardiomyocytes
SM Biendarra-Tiegs, FJ Secreto, TJ Nelson - Cell Biology and …, 2020 - Springer
Induced pluripotent stem cells (iPSCs) offer great promise in the areas of disease modeling,
basic research, drug development, and regenerative medicine. Much of their value comes …
basic research, drug development, and regenerative medicine. Much of their value comes …
Examining FKBP5 mRNA expression in human iPSC-derived neural cells
In peripheral blood leukocytes, FKBP5 mRNA expression is upregulated following
glucocorticoid receptor activation. The single nucleotide polymorphism rs1360780 in FKBP5 …
glucocorticoid receptor activation. The single nucleotide polymorphism rs1360780 in FKBP5 …