Atopic dermatitis: global epidemiology and risk factors

S Nutten - Annals of nutrition and metabolism, 2015 - karger.com
Atopic dermatitis (AD) is a chronic inflammatory skin disease posing a significant burden on
health-care resources and patients' quality of life. It is a complex disease with a wide …

New insights into the epidemiology of childhood atopic dermatitis

C Flohr, J Mann - Allergy, 2014 - Wiley Online Library
There is a growing desire to explain the worldwide rise in the prevalence of atopic dermatitis
(AD). Trend data on the burden of AD suggest that the picture in the develo** world may …

Efficacy and safety of abrocitinib in adults and adolescents with moderate-to-severe atopic dermatitis (JADE MONO-1): a multicentre, double-blind, randomised …

EL Simpson, R Sinclair, S Forman, A Wollenberg… - The Lancet, 2020 - thelancet.com
Background Abrocitinib, an oral selective Janus kinase 1 inhibitor, was effective and well
tolerated in adults with moderate-to-severe atopic dermatitis in a phase 2b trial. We aimed to …

Efficacy and safety of abrocitinib in patients with moderate-to-severe atopic dermatitis: a randomized clinical trial

JI Silverberg, EL Simpson, JP Thyssen… - JAMA …, 2020 - jamanetwork.com
Importance Abrocitinib, an oral, once-daily Janus kinase 1 selective inhibitor, was effective
and well tolerated in a phase 3 monotherapy trial of patients with moderate-to-severe atopic …

Global variations in prevalence of eczema symptoms in children from ISAAC Phase Three

JA Odhiambo, HC Williams, TO Clayton… - Journal of Allergy and …, 2009 - Elsevier
BACKGROUND: In 1999, The International Study of Asthma and Allergies in Childhood
(ISAAC) Phase One reported the prevalence of eczema symptoms in 715,033 children from …

Topical tofacitinib for atopic dermatitis: a phase IIa randomized trial

R Bissonnette, KA Papp, Y Poulin… - British Journal of …, 2016 - academic.oup.com
Background Despite unmet need, 15 years have passed since a topical therapy with a new
mechanism of action for atopic dermatitis (AD) has been approved. Janus kinase (JAK) …

[HTML][HTML] Eczema prevalence in the United States: data from the 2003 National Survey of Children's Health

TE Shaw, GP Currie, CW Koudelka… - Journal of Investigative …, 2011 - Elsevier
Using the 2003 National Survey of Children's Health sponsored by the federal Maternal and
Child Health Bureau, we calculated prevalence estimates of eczema nationally and for each …

Efficacy and safety of oral Janus kinase 1 inhibitor abrocitinib for patients with atopic dermatitis: a phase 2 randomized clinical trial

MJ Gooderham, SB Forman, R Bissonnette… - JAMA …, 2019 - jamanetwork.com
Importance Atopic dermatitis is associated with substantial patient and caregiver burden.
Currently available treatments for atopic dermatitis are inadequate or contraindicated for …

Mental health comorbidity in patients with atopic dermatitis

P Yaghmaie, CW Koudelka, EL Simpson - Journal of Allergy and Clinical …, 2013 - Elsevier
BACKGROUND: Recent data, primarily from Europe, suggest that children with atopic
dermatitis (AD) might be at increased risk of mental health disorders. OBJECTIVE: We aimed …

[HTML][HTML] Patient burden of moderate to severe atopic dermatitis (AD): insights from a phase 2b clinical trial of dupilumab in adults

EL Simpson, T Bieber, L Eckert, R Wu… - Journal of the American …, 2016 - Elsevier
Background The adult burden of atopic dermatitis (AD) is poorly characterized. Objective We
sought to characterize AD burden in adults with moderate to severe disease from the …