Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …

Routinely screened antibody fragments usually require further in vitro maturation to achieve
the desired biophysical properties. Blind in vitro strategies can produce improved ligands by …

To the Editor—For certain diseases, patients who have been previously infected by one
strain of a virus and who are later infected by another strain can suffer outcomes that are …

Here we review recent developments in mass spectrometry that have enabled its growing
contribution to the field of structural virology. Evidently, there is a strong renewed general …

Virtually all protein functions in the cell, including pathogenic processes, require coordinated
motion of atoms or domains, ie, conformational dynamics. Understanding protein dynamics …

Programmed cell death-1 (PD-1), an antigen co-receptor on cell surfaces, is one of the
conspicuous immune checkpoints. Nivolumab, a monoclonal antibody therapeutic approved …

Research into the basic biology of human health and disease, as well as translational
human research and clinical applications, all benefit from the growing accessibility and …

This review explores the diverse applications of deuterium in medicinal chemistry,
particularly as an analytical tool in mass spectrometry. Deuterium applications extend …

Solving the structure of an antibody-antigen complex gives atomic level information of the
interactions between an antibody and its antigen, but such structures are expensive and …