Vascular cognitive impairment

WM Van Der Flier, I Skoog, JA Schneider… - Nature reviews Disease …, 2018 - nature.com
The term vascular cognitive impairment (VCI) was introduced around the start of the new
millennium and refers to the contribution of vascular pathology to any severity of cognitive …

Impact of multiple pathologies on the threshold for clinically overt dementia

A Kapasi, C DeCarli, JA Schneider - Acta neuropathologica, 2017 - Springer
Longitudinal clinical–pathological studies have increasingly recognized the importance of
mixed pathologies (the coexistence of one or more neurodegenerative and cerebrovascular …

Diagnostic criteria for vascular cognitive disorders: a VASCOG statement

P Sachdev, R Kalaria, J O'Brien, I Skoog… - Alzheimer Disease & …, 2014 - journals.lww.com
Background: Several sets of diagnostic criteria have been published for vascular dementia
since the 1960s. The continuing ambiguity in vascular dementia definition warrants a critical …

Clinical presentations and epidemiology of vascular dementia

EE Smith - Clinical Science, 2017 - portlandpress.com
Cerebrovascular and cardiovascular diseases cause vascular brain injury that can lead to
vascular cognitive impairment (VCI). VCI is the second most common neuropathology of …

Pathology and pathogenesis of vascular cognitive impairment—a critical update

KA Jellinger - Frontiers in aging neuroscience, 2013 - frontiersin.org
Vascular cognitive impairment (VCI)[vascular cognitive disorder (VCD), vascular dementia]
describes a continuum of cognitive disorders ranging from mild cognitive impairment (MCI) …

MRI-visible perivascular space location is associated with Alzheimer's disease independently of amyloid burden

G Banerjee, HJ Kim, Z Fox, HR Jäger, D Wilson… - Brain, 2017 - academic.oup.com
Perivascular spaces that are visible on magnetic resonance imaging (MRI) are a
neuroimaging marker of cerebral small vessel disease. Their location may relate to the type …

Blood–brain barrier P-glycoprotein function in Alzheimer's disease

DME van Assema, M Lubberink, M Bauer… - Brain, 2012 - academic.oup.com
A major pathological hallmark of Alzheimer's disease is accumulation of amyloid-β in senile
plaques in the brain. Evidence is accumulating that decreased clearance of amyloid-β from …

Impact of molecular imaging on the diagnostic process in a memory clinic

R Ossenkoppele, ND Prins, YAL Pijnenburg… - Alzheimer's & …, 2013 - Elsevier
BACKGROUND:[11C] Pittsburgh compound B ([11C] PIB) and [18F]-2-fluoro-2-deoxy-D-
glucose ([18F] FDG) PET measure fibrillar amyloid-β load and glucose metabolism …

Associations between amyloid β and white matter hyperintensities: a systematic review

A Roseborough, J Ramirez, SE Black… - Alzheimer's & Dementia, 2017 - Elsevier
Introduction This systematic review synthesizes current evidence for associations between
cortical amyloid β, visualized on amyloid positron emission tomography imaging, and white …

Clinical and imaging features of mixed Alzheimer and vascular pathologies

HC Chui, L Ramirez-Gomez - Alzheimer's research & therapy, 2015 - Springer
The co-occurrence of both Alzheimer disease (AD) pathology and vascular brain injury (VBI)
is very common, especially amongst the oldest of old. In neuropathologic studies, the …