Genome-scale genetic screens allow researchers to rapidly identify the genes and proteins
that impact a particular phenotype of interest. In African trypanosomes, RNA interference …

The long and complex Trypanosoma brucei development in the tsetse fly vector culminates
when parasites gain mammalian infectivity in the salivary glands. A key step in this process …

Trypanosoma brucei and other African trypanosomes are vector‐borne parasites that cause
substantial human suffering across sub‐Saharan Africa. The T. brucei life cycle is …

Trypanosoma brucei is unusually reliant on mRNA-binding proteins to control mRNA fate,
because its protein-coding genes lack individual promoters. We here focus on three …

Trypanosoma and Leishmania parasites cause devastating tropical diseases resulting in
serious global health consequences. These organisms have complex life cycles with …

Post-transcriptional regulation of gene expression is particularly important in trypanosomatid
protozoa. RNA-binding proteins (RBPs) regulate mRNA stability and translation, yet …

Poly (A) Binding Proteins (PABPs) are major eukaryotic RNA-binding proteins (RBPs) with
multiple roles associated with mRNA stability and translation and characterized mainly from …

Trypanosoma cruzi, the etiological agent of Chagas disease, has a digenetic life cycle. In its
passage from the insect vector to the mammalian host, and vice versa, it must be prepared to …

The Trypanosoma (T) brucei life cycle alternates between the tsetse fly vector and the
mammalian host. In the insect, T. brucei undergoes several developmental stages until it …

While Entamoeba histolytica remains a globally important pathogen, it is dramatically
understudied. The tractability of E. histolytica has historically been limited, which is largely …