Tailor made: the art of therapeutic mRNA design
Abstract mRNA medicine is a new and rapidly develo** field in which the delivery of
genetic information in the form of mRNA is used to direct therapeutic protein production in …
genetic information in the form of mRNA is used to direct therapeutic protein production in …
Thoughts on how to think (and talk) about RNA structure
Recent events have pushed RNA research into the spotlight. Continued discoveries of RNA
with unexpected diverse functions in healthy and diseased cells, such as the role of RNA as …
with unexpected diverse functions in healthy and diseased cells, such as the role of RNA as …
Condensates in RNA repeat sequences are heterogeneously organized and exhibit reptation dynamics
Although it is known that RNA undergoes liquid–liquid phase separation, the interplay
between the molecular driving forces and the emergent features of the condensates, such as …
between the molecular driving forces and the emergent features of the condensates, such as …
LinearFold: linear-time approximate RNA folding by 5'-to-3'dynamic programming and beam search
Motivation Predicting the secondary structure of an ribonucleic acid (RNA) sequence is
useful in many applications. Existing algorithms [based on dynamic programming] suffer …
useful in many applications. Existing algorithms [based on dynamic programming] suffer …
Spatial organization of single mRNPs at different stages of the gene expression pathway
Summary mRNAs form ribonucleoprotein complexes (mRNPs) by association with proteins
that are crucial for mRNA metabolism. While the mRNP proteome has been well …
that are crucial for mRNA metabolism. While the mRNP proteome has been well …
mRNP architecture in translating and stress conditions reveals an ordered pathway of mRNP compaction
Stress granules (SGs) are transient membraneless organelles of nontranslating mRNA–
protein complexes (mRNPs) that form during stress. In this study, we used multiple single …
protein complexes (mRNPs) that form during stress. In this study, we used multiple single …
An RNA-based theory of natural universal computation
H Akhlaghpour - Journal of Theoretical Biology, 2022 - Elsevier
Life is confronted with computation problems in a variety of domains including animal
behavior, single-cell behavior, and embryonic development. Yet we currently do not know of …
behavior, single-cell behavior, and embryonic development. Yet we currently do not know of …
Measuring the conformation and persistence length of single-stranded DNA using a DNA origami structure
E Roth, A Glick Azaria, O Girshevitz, A Bitler… - Nano letters, 2018 - ACS Publications
Measuring the mechanical properties of single-stranded DNA (ssDNA) is a challenge that
has been addressed by different methods lately. The short persistence length, fragile …
has been addressed by different methods lately. The short persistence length, fragile …
mRNAs and lncRNAs intrinsically form secondary structures with short end-to-end distances
Abstract The 5′ and 3′ termini of RNA play important roles in many cellular processes.
Using Förster resonance energy transfer (FRET), we show that mRNAs and lncRNAs have …
Using Förster resonance energy transfer (FRET), we show that mRNAs and lncRNAs have …