Pseudomonas aeruginosa Biofilms

MTT Thi, D Wibowo, BHA Rehm - International journal of molecular …, 2020 - mdpi.com
Pseudomonas aeruginosa is an opportunistic human pathogen causing devastating acute
and chronic infections in individuals with compromised immune systems. Its highly notorious …

Tolerance and Resistance of Pseudomonas aeruginosa Biofilms to Antimicrobial Agents—How P. aeruginosa Can Escape Antibiotics

O Ciofu, T Tolker-Nielsen - Frontiers in microbiology, 2019 - frontiersin.org
Pseudomonas aeruginosa is one of the six bacterial pathogens, Enterococcus faecium,
Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas …

Mimicking biofilm formation and development: Recent progress in in vitro and in vivo biofilm models

I Guzmán-Soto, C McTiernan, M Gonzalez-Gomez… - Iscience, 2021 - cell.com
Biofilm formation in living organisms is associated to tissue and implant infections, and it has
also been linked to the contribution of antibiotic resistance. Thus, understanding biofilm …

Biofilm formation and inhibition mediated by bacterial quorum sensing

Y Wang, Z Bian, Y Wang - Applied Microbiology and Biotechnology, 2022 - Springer
As a complex microbial aggregate, biofilm is a group behavior of bacterial ability to adapt to
the environment. Bacteria produce biofilm substrates that enhance their tolerance to stress …

Regulation of Biofilm Exopolysaccharide Biosynthesis and Degradation in Pseudomonas aeruginosa

LZ Ma, D Wang, Y Liu, Z Zhang… - Annual review of …, 2022 - annualreviews.org
Microbial communities enmeshed in a matrix of macromolecules, termed as biofilms, are the
natural setting of bacteria. Exopolysaccharide is a critical matrix component of biofilms …

Pel is a cationic exopolysaccharide that cross-links extracellular DNA in the Pseudomonas aeruginosa biofilm matrix

LK Jennings, KM Storek, HE Ledvina… - Proceedings of the …, 2015 - National Acad Sciences
Biofilm formation is a complex, ordered process. In the opportunistic pathogen
Pseudomonas aeruginosa, Psl and Pel exopolysaccharides and extracellular DNA (eDNA) …

Genomic and Metabolic Characteristics of the Pathogenicity in Pseudomonas aeruginosa

T De Sousa, M Hébraud, MLNE Dapkevicius… - International journal of …, 2021 - mdpi.com
In recent years, the effectiveness of antimicrobials in the treatment of Pseudomonas
aeruginosa infections has gradually decreased. This pathogen can be observed in several …

Roles of Two-Component Systems in Pseudomonas aeruginosa Virulence

M Sultan, R Arya, KK Kim - International journal of molecular sciences, 2021 - mdpi.com
Pseudomonas aeruginosa is an opportunistic pathogen that synthesizes and secretes a
wide range of virulence factors. P. aeruginosa poses a potential threat to human health …

Antibiotic discovery: combatting bacterial resistance in cells and in biofilm communities

A Penesyan, M Gillings, IT Paulsen - Molecules, 2015 - mdpi.com
Bacterial resistance is a rapidly escalating threat to public health as our arsenal of effective
antibiotics dwindles. Therefore, there is an urgent need for new antibiotics. Drug discovery …

Pseudomonas biofilm matrix composition and niche biology

EE Mann, DJ Wozniak - FEMS microbiology reviews, 2012 - academic.oup.com
Biofilms are a predominant form of growth for bacteria in the environment and in the clinic.
Critical for biofilm development are adherence, proliferation, and dispersion phases. Each of …