BACKGROUND: The American Heart Association (AHA), in conjunction with the National
Institutes of Health, annually reports the most up-to-date statistics related to heart disease …

Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait
or disease and may become a valuable tool for advancing precision medicine. However …

Abstract Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse
pathophysiological processes, and molecular mechanisms that are often specific to cell …

Abstract Type 2 diabetes (T2D) is a multifactorial disease with substantial genetic risk, for
which the underlying biological mechanisms are not fully understood. In this study, we …

Diabetes, a complex multisystem metabolic disorder characterized by hyperglycemia, leads
to complications that reduce quality of life and increase mortality. Diabetes pathophysiology …

Cardiovascular health interacts with cognitive and mental health in complex ways, yet little is
known about the phenotypic and genetic links of heart-brain systems. We quantified heart …

Genome-wide association studies (GWAS) have provided insights into the genetic basis of
complex diseases. In the next step, integrative multi-omics approaches can characterize …

Background Type 2 diabetes mellitus (T2DM) is a chronic, metabolic disorder in which
concomitant insulin resistance and β-cell impairment lead to hyperglycemia, influenced by …

Dysfunctional pancreatic islet beta cells are a hallmark of type 2 diabetes (T2D), but a
comprehensive understanding of the underlying mechanisms, including gene dysregulation …

Abstract Type 2 diabetes (T2D) genome-wide association studies (GWASs) often overlook
rare variants as a result of previous imputation panels' limitations and scarce whole-genome …