Primary angle‐closure glaucoma is potentially a devastating disease, responsible for half of
glaucoma‐related blindness worldwide. Angle closure is characterized by appositional …

Eye formation is the result of coordinated induction and differentiation processes during
embryogenesis. Disruption of any one of these events has the potential to cause ocular …

Refractive error is the most common eye disorder worldwide and is a prominent cause of
blindness. Myopia affects over 30% of Western populations and up to 80% of Asians. The …

Myopia, or nearsightedness, is the most common eye disorder, resulting primarily from
excess elongation of the eye. The etiology of myopia, although known to be complex, is …

Nanophthalmos is a clinical spectrum of disorders with a phenotypically small but
structurally normal eye. These disorders present significant clinical challenges to …

Glaucoma is a family of diseases whose pathology is defined by the progressive loss of
retinal ganglion cells. Clinically, glaucoma presents as a distinctive optic neuropathy with …

Myopia is an extremely common eye disorder but the pathogenesis of its isolated form,
which accounts for the overwhelming majority of cases, remains poorly understood. There is …

The axial length of the eye is critical for normal visual function by enabling light to precisely
focus on the retina. The mean axial length of the adult human eye is 23.5 mm, but the …

Human eye development is coordinated through an extensive network of genetic signalling
pathways. Disruption of key regulatory genes in the early stages of eye development can …

Nanophthalmos is a rare, potentially devastating eye condition characterized by small eyes
with relatively normal anatomy, a high hyperopic refractive error, and frequent association …