As a central hub for cellular metabolism and intracellular signaling, the mitochondrion is a
pivotal organelle, dysfunction of which has been linked to several human diseases including …

Abstract Mitochondria contain about 1,000–1,500 proteins that fulfil multiple functions.
Mitochondrial proteins originate from two genomes: mitochondrial and nuclear. Hence …

Coenzyme Q (CoQ) is a remarkably hydrophobic, redox-active lipid that empowers diverse
cellular processes. Although most known for shuttling electrons between mitochondrial …

Mitochondria are multifaceted organelles with key roles in anabolic and catabolic
metabolism, bioenergetics, cellular signalling and nutrient sensing, and programmed cell …

Mitochondrial disease is hugely diverse with respect to associated clinical presentations and
underlying genetic causes, with pathogenic variants in over 300 disease genes currently …

Coenzyme Q (ubiquinone or CoQ) is an essential lipid that plays a role in mitochondrial
respiratory electron transport and serves as an important antioxidant. In human and yeast …

The genome of an organism is inherited from its ancestor and continues to evolve over time,
however, the extent to which the current version could be altered remains unknown. To …

Mitochondria perform crucial functions in cellular metabolism, protein and lipid biogenesis,
quality control, and signaling. The systematic analysis of protein complexes and interaction …

Multi-omics analysis is a powerful and increasingly utilized approach to gain insight into
complex biological systems. One major hindrance with multi-omics, however, is the lengthy …

State-of-the-art proteomics software routinely quantifies thousands of peptides per
experiment with minimal need for manual validation or processing of data. For the emerging …