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The molecular basis for cellular function of intrinsically disordered protein regions
Intrinsically disordered protein regions exist in a collection of dynamic interconverting
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …
Intrinsically disordered regions are poised to act as sensors of cellular chemistry
Intrinsically disordered proteins and protein regions (IDRs) are abundant in eukaryotic
proteomes and play a wide variety of essential roles. Instead of folding into a stable …
proteomes and play a wide variety of essential roles. Instead of folding into a stable …
Materials design by synthetic biology
Synthetic biology applies genetic tools to engineer living cells and organisms analogous to
the programming of machines. In materials synthetic biology, engineering principles from …
the programming of machines. In materials synthetic biology, engineering principles from …
When phased without water: biophysics of cellular desiccation, from biomolecules to condensates
The molecular machinery that enables life has evolved in water, yet many of the organisms
around us are able to survive even extreme desiccation. Especially remarkable are single …
around us are able to survive even extreme desiccation. Especially remarkable are single …
Non-model model organisms
Abstract Model organisms are widely used in research as accessible and convenient
systems to study a particular area or question in biology. Traditionally only a handful of …
systems to study a particular area or question in biology. Traditionally only a handful of …
Evo-physio: on stress responses and the earliest land plants
JMR Fürst-Jansen, S de Vries… - Journal of Experimental …, 2020 - academic.oup.com
Embryophytes (land plants) can be found in almost any habitat on the Earth's surface. All of
this ecologically diverse embryophytic flora arose from algae through a singular evolutionary …
this ecologically diverse embryophytic flora arose from algae through a singular evolutionary …
Emerging roles for phase separation in plants
The plant cell internal environment is a dynamic, intricate landscape composed of many
intracellular compartments. Cells organize some cellular components through formation of …
intracellular compartments. Cells organize some cellular components through formation of …
Clustering of aromatic residues in prion-like domains can tune the formation, state, and organization of biomolecular condensates: published as part of the …
In immature oocytes, Balbiani bodies are conserved membraneless condensates implicated
in oocyte polarization, the organization of mitochondria, and long-term organelle and RNA …
in oocyte polarization, the organization of mitochondria, and long-term organelle and RNA …
Relevance and regulation of cell density
Cell density shows very little variation within a given cell type. For example, in humans
variability in cell density among cells of a given cell type is 100 times smaller than variation …
variability in cell density among cells of a given cell type is 100 times smaller than variation …
Protecting proteins from desiccation stress using molecular glasses and gels
Faced with desiccation stress, many organisms deploy strategies to maintain the integrity of
their cellular components. Amorphous glassy media composed of small molecular solutes or …
their cellular components. Amorphous glassy media composed of small molecular solutes or …