The molecular basis for cellular function of intrinsically disordered protein regions

AS Holehouse, BB Kragelund - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Intrinsically disordered protein regions exist in a collection of dynamic interconverting
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …

Intrinsically disordered regions are poised to act as sensors of cellular chemistry

D Moses, GM Ginell, AS Holehouse… - Trends in biochemical …, 2023 - cell.com
Intrinsically disordered proteins and protein regions (IDRs) are abundant in eukaryotic
proteomes and play a wide variety of essential roles. Instead of folding into a stable …

Materials design by synthetic biology

TC Tang, B An, Y Huang, S Vasikaran, Y Wang… - Nature Reviews …, 2021 - nature.com
Synthetic biology applies genetic tools to engineer living cells and organisms analogous to
the programming of machines. In materials synthetic biology, engineering principles from …

When phased without water: biophysics of cellular desiccation, from biomolecules to condensates

PS Romero-Perez, Y Dorone, E Flores… - Chemical …, 2023 - ACS Publications
The molecular machinery that enables life has evolved in water, yet many of the organisms
around us are able to survive even extreme desiccation. Especially remarkable are single …

Non-model model organisms

JJ Russell, JA Theriot, P Sood, WF Marshall… - BMC biology, 2017 - Springer
Abstract Model organisms are widely used in research as accessible and convenient
systems to study a particular area or question in biology. Traditionally only a handful of …

Evo-physio: on stress responses and the earliest land plants

JMR Fürst-Jansen, S de Vries… - Journal of Experimental …, 2020 - academic.oup.com
Embryophytes (land plants) can be found in almost any habitat on the Earth's surface. All of
this ecologically diverse embryophytic flora arose from algae through a singular evolutionary …

Emerging roles for phase separation in plants

RJ Emenecker, AS Holehouse, LC Strader - Developmental Cell, 2020 - cell.com
The plant cell internal environment is a dynamic, intricate landscape composed of many
intracellular compartments. Cells organize some cellular components through formation of …

Clustering of aromatic residues in prion-like domains can tune the formation, state, and organization of biomolecular condensates: published as part of the …

AS Holehouse, GM Ginell, D Griffith, E Boke - Biochemistry, 2021 - ACS Publications
In immature oocytes, Balbiani bodies are conserved membraneless condensates implicated
in oocyte polarization, the organization of mitochondria, and long-term organelle and RNA …

Relevance and regulation of cell density

GE Neurohr, A Amon - Trends in cell biology, 2020 - cell.com
Cell density shows very little variation within a given cell type. For example, in humans
variability in cell density among cells of a given cell type is 100 times smaller than variation …

Protecting proteins from desiccation stress using molecular glasses and gels

GI Olgenblum, BO Hutcheson, GJ Pielak… - Chemical …, 2024 - ACS Publications
Faced with desiccation stress, many organisms deploy strategies to maintain the integrity of
their cellular components. Amorphous glassy media composed of small molecular solutes or …